Reisa Sperling MD

Dr. Reisa Sperling is a neurologist focused on the detection and treatment of Alzheimer’s disease, even before clinical symptoms are evident. She is the co-Principal Investigator, with Dr. Keith Johnson, of the Harvard Aging Brain Study in Boston. Her research uses neuroimaging and cognitive tests to understand the aging brain and the earliest changes associated with Alzheimer’s disease. Dr. Sperling is a Professor in Neurology at Harvard Medical School, Director of the Center for Alzheimer Research and Treatment at Brigham and Women’s Hospital, and Director of Neuroimaging for the Massachusetts ADRC at Massachusetts General Hospital. Dr. Sperling led the NIA-Alzheimer’s Association workgroup to develop guidelines for “Preclinical Alzheimer’s disease,” and currently serves on the Advisory Council of the National Institute on Aging. Dr. Sperling is also the Project Leader for the Anti-Amyloid Treatment in Asymptomatic AD (A4) study - a landmark secondary prevention trial in over 1000 clinically normal older individuals with PET amyloid imaging evidence of early Alzheimer’s disease pathology. Dr. Sperling is a 2015 awardee of the American Academy of Neurology Potamkin Prize, and was named one of the 2017 Most Disruptive Women to Watch in Healthcare.


Keith Johnson MD

Dr. Johnson is a Professor of Radiology and Neurology at the Harvard Medical School. He is also an Associate Radiologist and the Director of Molecular Neuroimaging in the Division of Nuclear Medicine and Molecular Imaging at the Massachusetts General Hospital (MGH). He also serves as an associate physician and staff neurologist in the Memory Disorders Unit at the Brigham and Women's Hospital as well as a Clinical Associate in Neurology at the MGH. He is co-director of the Neuroimaging Program of the Massachusetts Alzheimer's Disease Research Center and its Dominantly Inherited Alzheimer Network (DIAN) research initiatives. He oversees the Clinical Brain Positron Emission Tomography (PET) Service at the MGH and also practices as a neurologist that specializes in neurodegenerative disorders. Dr. Johnson also maintains an Internet teaching atlas of neuroimaging known as the Whole Brain Atlas. His major research interests include the early diagnosis and treatment monitoring of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and dementia with Lewy bodies.


Dorene Rentz PsyD

Dorene M. Rentz, PsyD, is a clinical neuropsychologist with dual appointments in the Departments of Neurology at Brigham and Women’s Hospital and Massachusetts General Hospital. She is an Associate Professor of Neurology at Harvard Medical School and serves as the Co-Director of the Center for Alzheimer Research and Treatment and the Director of Neuropsychology at the Massachusetts Alzheimer’s Disease Research Center. She is also the Clinical Core Leader of the Harvard Aging Brain Study and the Director of the Recruitment and Outreach Core. Her research focus has been on the early detection of preclinical Alzheimer’s disease, particularly in high functioning individuals. Her recent work involves exploring early cognitive changes using PET amyloid and tau imaging and sensitive memory techniques. She is leading the cognitive outcome assessment committee for the A4 secondary prevention trial in Preclinical Alzheimer’s disease and is a leader in developing optimal cognitive outcome measures for future Alzheimer Disease prevention studies. She helped develop the iPad cognitive battery in the A4 study and has explored the feasibility of doing iPad cognitive assessments in the clinic and home environments.


Rebecca E. Amariglio PhD


Deborah Blacker MD, PhD


Rachel Buckley PhD


Jasmeer P. Chhatwal MD, PhD


Brad Dickerson MD


Nancy Donovan MD


Michelle Farrell PhD


Jennifer Gatchel MD, PhD


Edmarie Guzmán-Vélez PhD


Heidi Jacobs PhD


Cristina Lois Gomez PhD


Gad Marshall MD


Kate Papp PhD


Julie Price PhD


Jeremy Pruzin MD


Yakeel Quiroz PhD


Aaron Schultz PhD


Jorge Sepulcre MD, PhD


Irina Skyler-Scott MD


Patrizia Vannini PhD


Hyun-Sik Yang MD


Remote Investigators

J. Alex Becker PhD

Randy Bucker PhD

Shelytia Cocroft PhD

Trey Hedden PhD

Bernard Hanseeuw MD, PhD

Willem Hujibers PhD

Scott McGinnis MD

Elizabeth Mormino PhD

Jenny S. Rabin PhD


Coordinators, Research Assistants and Study Staff

Kelsey Biddle


Colleen Fitzpatrick  MS


Christopher Gonzalez  MS


Hannah Klein


Lyssa Manning MS


Martha Muñiz MA


Aubryn Samaroo


Paige Sparks


Heirangi Torrico-Teave


Joshua Fuller


Olivia Hampton


Sam Katz


Kirsten Moody


Danielle Mayblyum


Kelsey Barolak MA


Zoe Rubinstein


Justin Sanchez


Administrative Staff

Dylan Kirn MPH


Michael Properzi


Matthew Scott


Interns and Volunteers

Matti Hartman


Harvard Aging Brain Alumni

Ana Eustace

Julia Sherman

Courtney Martin

Michaela Mentzer

Vaishnivi Rao

Sarah Wigman

Jon Bruno

Margaret Chute

Alex Dagley

Alayna Younger

Lesley Pepin

Jackie Maye

Chris Gidiscin

Lauren Wadsworth

Natacha Lorius

Caroline Sullivan

Marlie Philiossaint

Nayiri Arzoumanian

Elie Kercine

Jonathan Alverio

Samantha Mauro

Andrew Ward

Sehily Jaimes

Sarah Aghjayan

Tamy-Fee Meneide

Katie Munro

Victoria Jonas

Molly LaPoint

Maria Dekhtyar

Olivia Schnieder