Brain. 2015 Apr;138(Pt 4):932-45 doi: 10.1093/brain/awv011. 2015 Feb 12.

A gradient in cortical pathology in multiple sclerosis by in vivo quantitative 7 T imaging

Mainero C, Louapre C, Govindarajan ST, Giannì C, Nielsen AS, Cohen-Adad J, Sloane J, Kinkel RP.

Abstract

We used a surface-based analysis of T2* relaxation rates at 7 T magnetic resonance imaging, which allows sampling quantitative T2* throughout the cortical width, to map in vivo the spatial distribution of intracortical pathology in multiple sclerosis. Ultra-high resolution quantitative T2* maps were obtained in 10 subjects with clinically isolated syndrome/early multiple sclerosis (≤ 3 years disease duration), 18 subjects with relapsing-remitting multiple sclerosis (≥ 4 years disease duration), 13 subjects with secondary progressive multiple sclerosis, and in 17 age-matched healthy controls. Quantitative T2* maps were registered to anatomical cortical surfaces for sampling T2* at 25%, 50% and 75% depth from the pial surface. Differences in laminar quantitative T2* between each patient group and controls were assessed using general linear model (P

PMID: 25681411