About Our Lab | Research | People | Publications | Contact Us | Participate | Press | External Links


Neuroimaging Papers at MGH NMR Center from the Seidman Laboratory

1. Seidman LJ, Faraone SV, Goldstein JM, Goodman JM, Kremen WS, Matsuda G, Hoge EA, Kennedy D, Makris N, Caviness VS, Tsuang MT. Reduced subcortical brain volumes in nonpsychotic siblings of schizophrenic patients: A pilot MRI study. American Journal of Medical Genetics, Neuropsychiatric Genetics 1997; 74: 507-514. PMID: 9342202 PubMed

2. Seidman LJ, Breiter H, Goodman JM, Goldstein JM, Woodruff P, O'Craven K, Savoy R, Tsuang MT, Rosen BR. A functional magnetic resonance imaging study of auditory vigilance with low and high information processing demands. Neuropsychology 1998; 12: 505-518. PMID: 9805320 PubMed

3. Goldstein JM, Goodman JM, Seidman LJ, Kennedy DN, Makris N, Lee H, Tourville J, Caviness VS, Faraone SV, Tsuang MT. Cortical abnormalities in schizophrenia identified by structural magnetic resonance imaging. Archives of General Psychiatry 1999; 56: 537-547. Full Text

4. Bush G, Frazier JA, Rauch SL, Seidman LJ, Whalen PJ, Jenike MA, Rosen BR, Biederman J. Anterior cingulate cortex dysfunction in adults with attention-deficit hyperactivity disorder revealed by FMRI and the counting stroop task. Biological Psychiatry 1999; 45:1542-1552. PMID: 10376114 PubMed

5. Seidman LJ, Faraone SV, Goldstein JM, Goodman JM, Kremen WS, Toomey R, Tourville J,Kennedy D, Makris N, Caviness VS, Tsuang MT. Thalamic and amygdala-hippocampal volume reductions in first degree relatives of schizophrenic patients: An MRI-based morphometric analysis. Biological Psychiatry 1999; 46: 941-954. PMID: 10509177 PubMed

6. Tsuang MT, Seidman LJ, Faraone SV. New approaches to the genetics of schizophrenia: Neuropsychological and neuroimaging studies of nonpsychotic first degree relatives of people with schizophrenia. In: Gattaz WF, Hafner H, eds. The Fourth Symposium on the Search for the Causes of Schizophrenia .Vol. IV. (Balance of the Century). Berlin: Springer, 1999: 191-207.

7. Goldstein JM, Seidman LJ, Horton NJ, Makris N, Kennedy DN, Caviness VS, Faraone SV, Tsuang MT. Normal sexual dimorphism of the adult human brain assessed by in-vivo magnetic resonance imaging. Cerebral Cortex 2001; 11: 490-497. PDF

8. Rosas HD, Goodman J, Chen YI, Jenkins BG, Kennedy DN, Makris N, Patti MS, Seidman LJ, Beal MF, Koroshetz WJ. Striatal volume loss in HD as measured by MRI and the influence of CAG repeat. Neurology 2001; 57: 1025-1028. PMID: 11571328 PubMed

9. Goldstein JM, Seidman LJ, O?rien L, Horton NJ, Kennedy DN, Makris N, Caviness VS, Faraone SV, Tsuang MT. Impact of normal sexual dimorphism on sex differences in structural brain abnormalities in schizophrenia assessed by magnetic resonance imaging. Archives of General Psychiatry 2002; 59:154-164. PDF

10. Seidman LJ, Faraone SV, Goldstein JM, Kremen WS, Horton NJ, Makris N, Toomey R, Kennedy D, Caviness VS, Tsuang MT. Left hippocampal volume as a vulnerability indicator for schizophrenia: A magnetic resonance imaging morphometric study of non-psychotic first degree relatives. Archives of General Psychiatry 2002; 59: 839-849. PMID: 12215084 PDF

11. Seidman LJ, Valera E. The ADHD Brain. In: Biederman J, ed. ADHD: Current Understanding of Etiology, Diagnosis and Neurobiology. Hasbrouck Heights, NJ: Veritas Institute, 2002; 25-34.

12. Faraone SV, Seidman LJ, Kennedy D, Makris N, Caviness VS, Kremen WS, Goldstein JM, Toomey R,Tsuang MT. Structural brain abnormalities among relatives of patients with schizophrenia: Implications for linkage studies. Schizophrenia Research 2003; 60: 125-140. PMID: 12591577 PubMed

13. Seidman LJ, Pantelis C, Keshavan MS, Faraone SV, Goldstein JM, Horton NJ, Makris N, Falkai P, Caviness VS, Tsuang MT. A review and a new report of medial temporal lobe dysfunction as a vulnerability indicator for schizophrenia: A magnetic resonance imaging morphometric family study of the parahippocampal gyrus. Schizophrenia Bulletin 2003; 29: 803-828. PMID: 14989416 PDF

14. Rosas HD, Koroshetz WJ, Chen YI, Skeuse C, Vangel M, Cudkowicz ME, Caplan K, Marek K, Seidman LJ, Jenkins BG, Makris N, Goldstein JM. Evidence for more widespread cerebral pathology in early HD: An MRI-based morphometric analysis. Neurology 2003; 60:1615-1620. PMID: 12771251 PubMed

15. Seidman LJ, Wencel HE, McDonald C, Murray R, Tsuang MT. Neuroimaging studies of non-psychotic first degree relatives of people with schizophrenia: Towards a neurobiology of vulnerability to schizophrenia. In Stone WS, Faraone SV, Tsuang MT, eds. Early Clinical Intervention and Prevention in Schizophrenia. Totowa, NJ; The Humana Press, Inc. 2003, 179-210.

16. Thermenos HW, Seidman LJ, Breiter H, Goldstein JM, Goodman JM, Poldrack R, Faraone SV, Tsuang MT. Functional MRI during auditory verbal working memory in non-psychotic relatives of persons with schizophrenia: A pilot study. Biological Psychiatry 2004; 55:490-500. PMID: 15023577 PubMed

17. Fischl B, Destrieux C, Halgren E, Gonne FS, Salat DH, Busa E, Seidman LJ, Goldstein JM, Kennedy D, Caviness D, Makris N, Rosen B, Dale A. Automatically parcellating the human cortex. Cerebral Cortex 2004; 14: 11-22. PMID: 14654453 PDF

18. Makris N, Gasic GP, Seidman LJ, Goldstein JM, Gastfriend D, Albaugh DM, Hodge SM, Kennedy D, Caviness VS, Tsuang MT, Hyman S, Rosen BR, Breiter HC. Decreased absolute volume in cocaine addicts. Neuron, 2004; 44: 729-740. PMID: 15541319 Full Text

19. Seidman LJ, Valera E, Bush G. Brain function and structure in adults with Attention-Deficit Hyperactivity Disorder. Psychiatric Clinics of North America, 2004; 27: 323-347. PMID: 15064000 PubMed

20. Stone WS, Thermenos HW, Tarbox SI, Poldrack RA, Seidman LJ. Medial temporal and prefrontal lobe activation and memory following glucose ingestion: A pilot fMRI study. Neurobiology of Learning and Memory 2005; 83: 54-64. PMID: 15607689 PubMed

21. Frazier JA, Chiu S, Breeze JL, Makris N, Lange N, Kennedy DN, Herbert MR, Bent EK, Koneru VK, Dieterich ME, Hodge SM, Rauch SL, Grant PE, Cohen BM, Seidman LJ, Caviness VS, Biederman J. Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder. American Journal of Psychiatry 2005; 162: 1256-1265. PDF

22. Thermenos HW, Goldstein, JM, Buka SL, Poldrack RA, Koch JK, Tsuang MT, Seidman LJ. The effect of working memory performance on fMRI in schizophrenia. Schizophrenia Research 2005; 74: 179-194. PMID: 15721998 PubMed

23. Goldstein JM, Jerram MW, Anagnoson R, Breiter H, Makris N, Goodman JM, Poldrack R, Tsuang MT, Seidman LJ. Sex differences in prefrontal cortical brain activity during fMRI of auditory verbal working memory. Neuropsychology 2005; 19: 509-519. PMID: 16060826 PDF

24. Valera E, Faraone SV, Biederman J, Poldrack R, Seidman LJ. Functional neuroanatomy of working memory in adults with ADHD. Biological Psychiatry 2005; 57:439-447. PMID: 15737657 PubMed

25. Makris N, Schlerf JE, Hodge SM, Haselgrove C, Albaugh MD, Seidman LJ, Rauch SL, Harris GJ, Biederman J, Caviness VS, Kennedy DN, Schmahmann. MRI-based surface assisted parcellation of human cerebellar cortex: An anatomically specified method with estimate of reliability. NeuroImage 2005; 25: 1146-1160. PMID: 15850732 PubMed

26. Seidman LJ, Valera EM, Makris NM. Structural brain imaging in adult ADHD. Biological Psychiatry 2005; 57: 1263-1272. PMID: 15949998 PubMed

27. Bush G, Valera EM, Seidman LJ. Functional neuroimaging of attention-deficit/hyperactivity disorder: A review and suggested future directions. Biological Psychiatry 2005; 57: 1273-1284. PMID: 15949999 PubMed

28. Goldstein JM, Jerram M Poldrack R Ahern T, Kennedy DN, Seidman LJ, Makris NM. Hormonal cycle modulates arousal circuitry using fmri. Journal of Neuroscience 2005; 25: 9309-9316. PMID: 16207891 PDF

29. Frazier JA, Breeze JL, Makris N, Giuliano A, Herbert MR, Seidman LJ, Biederman J, Hodge SM, Dietrich?E, Gerstein E, Kennedy DN, Rauch SL, Cohen B, Caviness VS. Cortical gray matter differences identified by structural magnetic resonance imaging in pediatric BPD. Bipolar Disorders 2005: 7: 555-569. PMID: 16403181 PubMed

30. Makris N, Goldstein JM, Kennedy D, Hodge SM, Caviness VS, Faraone SV, Tsuang MT, Seidman LJ. Decreased volume of left and total anterior insular lobule in schizophrenia. Schizophrenia Research 2006: 83: 155-171. PMID: 16448806 PubMed

31. Seidman LJ, Thermenos HW, Poldrack RA, Peace NK, Koch JK, Faraone SV, Tsuang MT. Altered brain activation in dorsolateral prefrontal cortex in adolescents and young adults at genetic risk for schizophrenia: An fMRI study of working memory. Schizophrenia Research 2006; 85:58-72. PMID: 16632333 PubMed

32. Makris NM, Kaiser JR, Haselgrove C, Seidman LJ, Biederman J, Boriel D, Valera EM, Papadimitriou GM, Fischl B, Caviness VS, Kennedy DN. Human cerebral cortex: a system for the integration of volume- and surface-based representations. NeuroImage 2006; 33: 139-153. PMID: 16920366 PubMed

33. O'Brien LM, Ziegler DA, Deutsch CK, Kennedy DN, Goldstein JM, Seidman LJ, Hodge S, Makris N, Caviness V, Frazier JA, Herbert MR. Adjusting whole brain and cranial size in volumetric brain studies: A review of common adjustment factors and statistical methods. Harv Rev Psychiatry, 2006; 14:141-151. Abstract

34. Seidman LJ, Valera EM, Makris N, Monuteaux MC, Boriel DL, Kelkar K, Kennedy DN, Caviness VS, Bush G, Aleardi M, Faraone SV, Biederman J. Dorsolateral prefrontal and anterior cingulate cortex volumetric abnormalities in adults with attention-deficit/hyperactivity disorder identified by magnetic resonance imaging. Biological Psychiatry, 2006; 60:1071-1080. PMID: 16876137 PubMed

35. Thermenos HW, Seidman LJ, Poldrack RA, Peace NK, Koch JK, Faraone SV, Tsuang MT. Elaborative verbal encoding and altered anterior parahippocampal activation in adolescents and young adults at genetic risk for schizophrenia using fMRI. Biological Psychiatry 2007 61:564-574. PMID: 17276751 PubMed

36. Goldstein JM, Seidman JL, Makris N, Ahern T, O'Brien LM, Caviness VS, Kennedy DN, Faraone SV, Tsuang, MT. Hypothalamic abnormalities in schizophrenia: Sex effects & genetic vulnerability. Biological Psychiatry 2007; 61: 935-945. PMID: 17046727 PDF

37. Valera EM, Faraone SV, Murray KE, Seidman LJ. Meta-analysis of structural imaging findings in ADHD. Biological Psychiatry 2007; 61: 1361-1369. PMID: 16950217 PubMed

38. Keuthen NJ, Makris N, Schlerf JE, Martis B, Savage CR, McMullin K, Seidman LJ, Schmahmann J, Kennedy DN, Hodge SM, Rauch SL. Evidence for reduced cerebellar volumes in trichotillomania. Biological Psychiatry 2007; 61: 374-381. PMID: 16945351 PubMed

39. Makris NM, Biederman J, Valera EM, Bush G, Kaiser JR, Kennedy DN, Caviness VS, Faraone SV, Seidman LJ. Cortical thinning of the attention and executive function networks in adults with Attention-Deficit/Hyperactivity Disorder. Cerebral Cortex 2007; 17: 1364-1375. PMID: 16920883 PubMed

40. Walder DJ, Seidman LJ, Makris N, Tsuang MT, Kennedy DN, Goldstein JM. Neuroanatomic substrates of sex differences in language dysfunction in schizophrenia: A pilot study. Schizophr Res 2007; 90: 295-301. PMID: 17150336 Full Text

41. Ahn M, Breeze JL, Makris N, Kennedy DN, Herbert MR, Hodge SM, Seidman LJ, Biederman J, Caviness VS, Frazier JA. Anatomic brain magnetic resonance imaging (MRI) study of basal ganglia in pediatric bipolar isorder. J Affective Disorders 2007; 104: 147-154. PMID: 17532475 PubMed

42. Seidman LJ, Thermenos HW, Koch JK, Ward M, Breiter H, Goldstein JM, Goodman JM, Faraone SV, Tsuang MT. Auditory verbal working memory load and thalamic activation in non-psychotic relatives of persons with schizophrenia: An FMRI replication. Neuropsychology 2007; 21: 599-610. PMID: 17784808 PubMed

43. Bush G, Spencer TJ, Holmes J, Shin LM, Valera EM, Seidman LJ, Makris N, Surman C, Aleardi M, Mick E, Biederman J. Functional magnetic resonance imaging of methylphenidate and placebo in attention-deficit/hyperactivity disorder during the multi-source interference task. Archives General Psychiatry 2008; 65: 102-114. PMID: 18180434 PubMed

44. Frazier JA, Hodge SM, Breeze JL, Giuliano AJ, Terry JE, Moore CM, Kennedy DN, Lopez-Larson MP, Caviness VS, Seidman LJ, Zablotsky B, Makris N. Diagnostic and sex effects on limbic volumes in early-onset bipolar disorder and schizophrenia. Schizophr Bull 2008; 34:37-46. PDF

45. Biederman J, Makris N, Valera EM, Monuteaux MC, Goldstein JM, Buka S, Boriel DL, Bandyopadhyay S, Kennedy DN, Caviness VS, Bush G, Aleardi M, Hammerness P, Faraone SV, Seidman LJ. Towards further understanding of the comorbidity between attention deficit hyperactivity disorder and bipolar disorder: A MRI study of brain volumes. Psychological Medicine 2008; 38: 1045-1056. PMID: 17935640 PubMed

46. Makris NM, Buka SL, Biederman J, Papadimitriou GM, Hodge SM, Valera EM, Brown A, Bush G, Monuteaux MC, Caviness VS, Kennedy DN, Seidman LJ. Attention and executive systems abnormalities in adults with childhood ADHD: A DT-MRI study of connections. Cerebral Cortex 2008; 18:1210-1220. PMID: 17906338 PDF

47. Makris N, Gasic GP, Kennedy DN, Hodge SM, Kaiser,JR, Lee M, Kim BW, Blood AJ, Evins AE,Seidman LJ, Iosifescu D, Lee S, Baxter C, Perlis RH, Smoller JW, Fava M, Breiter HC. Cortical Thickness Abnormalities in Cocaine Addiction—A Reflection of Both Drug Use and a Pre-existing Disposition to Drug Abuse? Neuron 2008; 60:174-188. PMID: 18940597 PubMed

48. Monuteaux MC, Seidman LJ, Faraone SV, Makris N, Spencer T, Valera E, Brown A, Bush G, Doyle AE, Hughes S, Helliesen M, Mick E, Biederman J. A preliminary study of dopamine D4 receptor genotype and structural brain alterations in adults with ADHD. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 147B:1436–1441. Abstract

49. Makris NM, Seidman LJ, Valera EM, Monuteaux MC, Kennedy DN, Caviness VS, Crum K, Brown AB, Bush G, Faraone SV, Biederman J. Anterior cingulate volumetric alterations in treatment-naive adults with ADHD: A pilot study. J Attention Disorders (In Press).

50. MacDonald A, Thermenos HW, Barch D, Seidman LJ. Imaging genetic liability to schizophrenia: Systematic review of fMRI studies of patients' non-psychotic relatives. Schizophr Bull (In Press).

51. Makris N, Biederman J, Monuteaux MC, Seidman LJ. Towards conceptualizing a systems neuroanatomy of Attention-Deficit/Hyperactivity Disorder. Developmental Neuroscience 2009;21:36-49. PMID: 19372685 PubMed

52. S Whitfield-Gabrieli, HW Thermenos, S Milanovic, MT Tsuang, SV Faraone, RW. McCarley, ME. Shenton, AI Green, J Wojcik, JDE Gabrieli, LJ Seidman. Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia. Proceedings of the National Academy of Sciences 2009; 106(4):1279-1284. PMID: 19164577 PubMed

53. Thermenos HW, Goldstein JM, Milanovic SM, Gabrieli SW, Makris N, LaViolette P, Koch JR, Faraone SV, Tsuang MT, Buka SL, Seidman LJ (In Press). An fMRI study of working memory in persons with bipolar disorder or genetic risk for bipolar disorder. Neuropsychiatric Genetics 99999:1-12. PMID: 19418510 PubMed

54. Makris NM, Seidman LJ, Valera EM, Monuteaux MC, Kennedy DN, Caviness VS, Crum K, Brown AB, Bush G, Faraone SV, Biederman J. Anterior cingulate volumetric alterations in treatment-naïve adults with ADHD: A pilot study. J Attention Disorders (In Press).

55. Brown AB, Biederman J, Valera EM, Doyle AE, Bush G, Spencer T, Monuteaux MC, Mick E, Gabrieli-Whitfield S, Makris N, LaViolette PS, Oscar-Berman M, Faraone SV, Seidman LJ. Effect of dopamine transporter gene (SLC6A3) variation on dorsal anterior cingulate function in ADHD. Neuropsychiatric Genetics (In Press). PMID: 19676101 PubMed

56. Valera EM, Brown A, Biederman J, Faraone SV, Makris N, Monuteaux MC, Gabrieli-Whitfield S, Vitulano M, Schiller M, Seidman LJ. Sex differences in the functional neuroanatomy of working memory in adults with ADHD. Am J Psychiatry (In Press).

57. Rimol, LM, Eyler, LT, Fennema-Notestine C, Fischl B, Franz CE, Hagler D, Lyons MJ, Neale MC, Pacheco J, Perry ME, Panizzon MS, Schmitt JE, Seidman LJ, Thermenos H, Tsuang MT, Kremen WS, Dale AM (In Press). Cortical thickness is influenced by regionally-specific genetic factors. Biological Psychiatry. Abstract

58. Kremen W, Prom-Wormley E, Panizzon M, Eyler L, Fischl B, Neale M, Franz C, Lyons M, Pacheco J, Perry M, Stevens A, Schmitt JE, Grant M, Seidman L, Thermenos H, Tsuang M, Eisen S, Dale A, Fennema-Notestine C (In Press): Genetic and environmental influences on the size of specific brain regions in midlife: The VETSA MRI study. Neuroimage. PMID: 19786105 PubMed

59. Eyler, LT, Prom-Wormley E, Fennema-Notestine C, Panizzon MS, Neale MC, Jernigan TL, Fischl B,Franz CE, Lyons MJ, Stevens A, Pacheco J, Perry ME, Schmitt JE, Spitzer NC, Seidman LJ, Thermenos H, Tsuang MT, Dale AM, Kremen WS. Genetic patterns of correlation among subcortical volumes in humans: Results from a magnetic resonance imaging twin study. Human Brain Mapping (In Press).