David Alan Boas

Education

Rensselaer Polytechnic Institute, Troy, NY 12180
Bachelor of Science, received May 1991
Major: Physics. Minor: Philosophy of Science. GPA 3.2/4.0
Elected into Sigma Phi Sigma, the National Physics Honorary Society, 1991

Experience

Nuclear Magnetic Resonance Center, Massachusetts General Hospital. Developing and applying diffuse optical tomography to clinical problems and basic research in physiology. Advising graduate students.

Assistant Physicist, Massachusetts General Hospital September 1998 – present

Nuclear Magnetic Resonance Center, Massachusetts General Hospital. Developing and applying diffuse optical tomography to clinical problems and basic research in physiology. Advising graduate students.

Assistant Research Professor, Tufts University September 1996 - present

Electro-Optic Technology Center, Department of Electrical Engineering and Computer Science, Tufts University. Teaching graduate courses in the field of electro-optics and running a research program in biomedical optics with the assistance of graduate students.

Assistant Professor, Tufts University (secondary appointment) September 1996 – August 1997

Department of Ophthalmology, New England Eye Center, Tufts University. Bio-optics research applied to ophthalmology. Advising students.

Research Assistant, University of Pennsylvania June 1992-August 1996

Dr. Arjun Yodh, Department of Physics and Astronomy, and Dr. Britton Chance, Department of Biochemistry and Biophysics, University of Pennsylvania. Actively contributing to the development of a medical optical imaging modality. Responsible for signal-to-noise analysis that determines the ultimate resolution for optical imaging. Developing a coherence technique for imaging dynamical properties of turbid media. Developing large scale serial and parallel programs used internationally.

Research Supervisor, University of Pennsylvania 1993-May 1996

Advising of undergraduates leading to co-authored publications and an advisee presentation at a meeting of the Optical Society of America.

Teaching Assistant, University of Pennsylvania Summer 1994, Fall 1994

Dr. Paul Soven and Dr. Larry Gladney, Department of Physics and Astronomy, University of Pennsylvania. Assisted in the development, teaching, and grading of a new computer-oriented Physics I laboratory.

Research Assistant, University of Pennsylvania Spring 1992

Dr. Roy Middleton, Department of Physics and Astronomy, University of Pennsylvania. Developed a computer program to calculate the charge state fractionation of an ion in a Tandem accelerator and compare it to a library of experimental results.

Teaching Assistant, University of Pennsylvania Fall 1991

Dr. Tom Lubensky, Department of Physics and Astronomy, University of Pennsylvania. Supervised and graded three sections of Physics I laboratory.

Project Engineer, General Electric Summer 1987, Summer 1988, Winter 1988, Winter 1989, Fall 1990, June 1991

Advanced Technology Laboratories, GE, Moorestown, NJ. Member of the Intelligent Systems Group. Programmed a massively parallel computer to solve the diffusion equation. Experimented with developmental graphics systems. Created real time graphic simulations of proposed projects. Developed software for testing robot control and machine vision algorithms.

Praktikon, Paul Scherrer Institute Summer 1990

Dr. Rudolf Rosel, Paul Scherrer Institute, Villigen, Switzerland. Mathematically analyzed elastic systems to locate and analyze the points of bifurcation and subsequent breaks in symmetry.

Research Assistant, Rensselaer Polytechnic Institute Summer 1989-Spring 1990

Dr. Marc Kutner, Physics Department, Rensselaer Polytechnic Institute. Analyzed observational data of the Magellanic Clouds using the computer capabilities of UNIX-based IRIS and SUN workstations.

Teaching Assistant, Rensselaer Polytechnic Institute Fall 1989

Dr. Shannon, Physics Department, Rensselaer Polytechnic Institute. Taught and graded two sections of Physics III laboratory.

Professional Activities

Conference Program Committees: OSA Advances in Photon Migration Topical Meeting 2000, Optical Society of America (OSA) Conference on Lasers and Electro-Optics 1999, OSA Advances in Photon Migration Munich meeting 1999, OSA Annual Meeting 1998, OSA Advances in Photon Migration Topical Meeting 1998, Saratov Fall Meeting on Biomedical Optics 1998-2000.

OSA New Focus Student Award Selection Committee, Member 1998

Biomedical Optical Spectroscopy Technical Council, Optical Society of America Vice-Chair 1997, Chair 1997-1999. Organized meeting on the State of Diffuse Optical Tomography at the OSA annual meeting 1998.

Associate Editor of Optics Express, an electronic journal from the Optical Society of America 1997-present

OpticsNet Committee, ad hoc member, Optical Society of America 1997-present

Bio-Optics Ad Hoc Committee, member, Optical Society of America 1996-present

An editor of BioOptics OnLine, and electronic magazine from the Optical Society of America 1996-1998

Started and maintaining an e-mail discussion group for researchers in the field of photon migration/optical imaging. The group currently has 300+ international subscribers. 1995-present

3 patents and 2 patent applications. 1993, 1996, 1999

Publications – Journals

Richard J Gaudette, Dana H Brooks, Charles A DiMarzio, Misha E Kilmer, Eric L Miller, Thomas Gaudette and David A Boas, "A comparison study of linear reconstruction techniques for diffuse optical tomographic imaging of absorption coefficient," Phys. med. Biol. 45:1051-1070 (2000).

David A. Benaron, Susan R Hintz, Arno Villringer, David Boas, Andreas Kleinschmidt, Jens Frahm, Christina Hirth, Hellmuth Obrig, John C. van Houten, Eben L. Kermit, Wai-Fung Cheong, David K. Stevenson, "Noninvasive functional imaging of the human brain using light," J. Cerebral Blood Flow and Metabolism 20: 469-477 (2000).

Cheng, X., and Boas, D.A., "Systematic diffuse optical image errors resulting from uncertainty in the background optical properties," Optics Express 4:299-307 (1999).

Siegel, A.M., Marota, J.J.A., and Boas, D.A., "Design and evaluation of a continuous-wave diffuse optical tomography system," Optics Express 4:287-298 (1999).

Cheng, X., and Boas, D. A., "Diffuse Optical Reflection Tomography with Continuous Illumination," Optics Express 3:118-123 (1998).

Bizheva, K. K., Siegel, A. M., and Boas, D. A., "Pathlength resolved dynamic light scattering in highly scattering random media: the transition to diffusing wave spectroscopy," Phys. Rev. E 58:7664-7667 (1998).

Boas, D.A., Bizheva, K.K., and Siegel, A.M., "Using Low Coherence Domain Reflectometry to Image Brownian Motion within Highly Scattering Media," Optics Letters 23:319-321 (1998).

Walker, S.A., Boas, D.A., and Gratton, E. "Photon density waves scattered from cylindrical inhomogeneities: Theory and Experiments," Applied Optics 37:1935-1944 (1998).

Boas, D. A., "A fundamental limitation of linearized algorithms for diffuse optical tomography," Optics Express 1:404-413 (1997).

Durduran, T., B. Chance, A. G. Yodh, and D. A. Boas, "Does the photon diffusion coefficient depend on absorption?" J. Opt. Soc. Am. A 14:3358-3365 (1997).

Boas, D. A., and A. G. Yodh, "Spatially Varying Dynamical Properties of Turbid Media Probed with Diffusing Temporal Light Correlation," JOSA A 14:192-215 (1997).

Boas, D. A., M. A. O'Leary, B. Chance, and A. G. Yodh, "Detecting and characterizing optical inhomogeneities with diffuse photon density waves: A signal-to-noise analysis," Applied Optics 36:75-92 (1997).

O'Leary, M. A., D. A. Boas, X. Li, B. Chance, and A. G. Yodh, "Fluorescence lifetime imaging in turbid media," Optics Letters, 21:158-160 (1996).

Li X., M. A. O'Leary, D. A. Boas, B. Chance, and A. G. Yodh, "Fluorescent diffuse photon density waves in homogeneous and heterogeneous media: Analytic solutions and sensitivity analysis," Applied Optics, 31:3746-3758 (1996).

Boas D. A., L. E. Campbell, and A. G. Yodh, "Scattering and imaging with diffusing temporal field correlation," Phys. Rev. Lett, 75:1855-1858 (1995).

Liu H., D. A. Boas, Y. Zhang, A. G. Yodh, and B. Chance, "Determination of optical properties and blood oxygenation using continuous NIR light," Phys. Med. Biol., 40:1983-1993 (1995).

O'Leary M. A., D. A. Boas, B. Chance, and A. G. Yodh, "Experimental images of heterogeneous turbid media by frequency-domain diffusing-photon tomography," Optics Letters, 20:426-428 (1995).

O'Leary M. A., D. A. Boas, B. Chance, and A. G. Yodh, "Reradiation and imaging of diffuse photon density waves using fluorescent inhomogeneities," Journal of Luminescence," 60:281-286 (1994).

Boas D. A, M. A. O'Leary, B. Chance, and A. G. Yodh, "Scattering of diffuse photon density waves by spherical inhomogeneities within turbid media," Proc. Natl. Acad. Sci. USA, 91:4887-4891 (1994).

Boas D. A., M. A. O'Leary, B. Chance, and A. G. Yodh, "Scattering and wavelength transduction of diffuse photon density waves," Phys. Rev. E, 47:R2999-R3002 (1993).

O'Leary M. A., D. A. Boas, B. Chance, and A. G. Yodh, "Refraction of diffusion photon density waves," Phys. Rev. Lett., 69:2658-2661 (1992).

Publications - Book Chapter

Ramanujam, N., Boas, D. A., and Li, Y., "Laser Spectroscopy and Imaging for Characterization of Human Tissue," in Lasers in Surface Engineering, ed. N. B. Dahotre (American Society for Materials, Ohio, 1998).

Stankovic, M.R., Maulik, D., Boas, D., and Stubblefield, P.G., "Emerging Technologies: Fetal Optical Monitoring, in Asphyxia and Fetal Brain Damage," M. D, Editor. 1998, John Wiley & Sons, Inc.: New York. p. (In Press).

Boas D. A., I. V. Meglinsky, L. Zemany, L. E. Campbell, B. Chance, and A. G. Yodh, "Diffusion of temporal field correlation with selected applications," SPIE Coherence-Domain Methods in Biomedical Optics, edited by Valery Tuchin, 2732:34-46 (1996).

Invited Conference Presentations

Boas, D. A., "Optical Imaging: Seeing into the brain," Harvard Medical School Department of Continuing Education course on Clinical Functional MRI, Boston, MA, May, 2000.

Boas, D.A., and K. Bizheva, "The effect of multiply scattered light on the imaging point spread function of optical coherence tomography," Workshop on Coherent Optics of Random Media, Saratov Fall Meeting October 2000, Saratov, Russia.

Boas, D.A., and X. Cheng, "Near Infrared Spectroscopy of Focal Hemoglobin Changes," International Symposia on Industrial Lasers and Biomedical Optics IL'99 and BiOS'99, October 1999, Wuhan, China.

Boas, D.A., X. Cheng, and T. Gaudette, "A Model-Based Calibration Method for Diffuse Optical Tomography," NIH Workshop on In-Vivo Biomedical Optics, September 1999, Bethesda, Md.

Boas, D.A., "Diffuse Optical Tomography: The Basics," Human Brain Mapping, June 1999, Dusseldorf, Germany.

Boas, D.A., "Optical Mammography," Engineering Foundation Conference, Aug. 1-5, 1999, Kona, Hawaii.

Boas, D.A., and K. Bizheva, "The Effects of Multiple Light Scattering on Optical Coherence Tomography," Summer School on Waves and Imaging through Complex Media, Cargese, Corsica, France, Aug. 30 – Sept. 3, 1999.

Boas D. A., "Imaging in the single scattering, few scattering, and light diffusion regimes with low-coherent light," SPIE/BioS West, Jan. 1999, San Jose, CA.

Boas, D. A., "Optical Imaging: Seeing into the future," Harvard Medical School Department of Continuing Education course on Clinical Functional MRI, Boston, MA, Oct. 13-15, 1998.

Boas D. A., "Optical Imaging in Tissue (Mammography)," OSA Annual Meeting, Workshop on Emerging Technologies in Biomedical Optics, Oct. 7, 1998, Baltimore, MD.

D. A. Boas, A. M. Siegel, X. Cheng, B. Chance, "An effective continuous-wave diffuse optical tomography system for anatomical and functional tissue imaging," SPIE Photonics China, Sept.16-19, 1998, Beijing, China.

Boas D. A., "Light scattering: the transition from single scattering to light diffusion," Gordon Conference on Lasers in Biology and Medicine, June 1998, New Hampshire.

Boas D. A., "Images of motions in highly scattering media with diffusing temporal correlation," Engineering Foundation Conference, July 16, 1997, Snowbird, Utah.

Conference Presentations

P. Ellen Grant, Anna Zourabia, Kalpathy S Krishnamoorthy, Robert M. Insoft,David A. Boas. "Spatially Resolved Near Infrared Spectroscopy of the Human Newborn Brain," May, 2000, Boston, MA.

Bizheva K., D.A. Boas, "Wave model of the effect of multiply scattered light in confocal and optical coherence microscopes," SPIE/BioS West, Jan. 1999, San Jose, CA.

Siegel A. M., J. Marota, J. Mandeville, B. Rosen, and D. A. Boas, "Diffuse Optical Tomography of Rat Brain Function: A Comparative Study with fMRI," SPIE/BioS West, Jan. 1999, San Jose, CA.

Cheng X., D. A. Boas, "A hybrid method for three dimensional, quantitative imaging of heterogeneous turbid medium using diffuse light," SPIE/BioS West, Jan. 1999, San Jose, CA.

Hintz S., A. M. Siegel, D. A. Benaron,and D. A. Boas, "Bedside functional imaging of the premature infant brain during passive motor activation," SPIE/BioS West, Jan. 1999, San Jose, CA.

Gaudette R. J., D. A. Boas, D. H. Brooks, C. A. DiMarzio, and E. L. Miller, "A Comparison of Linear Reconstruction Techniques for 3D DPDW Imaging of Absorption Coefficient," SPIE/BioS West, Jan. 1999, San Jose, CA.

Kilmer M. E., D. A. Boas, D. H. Brooks, C. A. DiMarzio, R. J. Gaudette, and E. L. Miller, "Nonlinear Inverse Scattering Methods for Diffuse Photon Density Wave Imaging," SPIE/BioS West, Jan. 1999, San Jose, CA.

Cheng X., D. A. Boas, "Diffuse optical diffraction tomography in reflectance mode," OSA Annual Meeting, Oct. 8, 1998, Baltimore, MD.

Boas D. A., "Preliminary diffuse optical tomography results of cerebral hemodynamics obtained with a continuous wave imaging system," Conference on Lasers and Electro-Optics, Optical Society of America, May 4-8, 1998, San Francisco, CA.

Bizheva, K., A. M. Siegel, and D. A. Boas, "Optical coherence microscopy of Brownian motion as a tool for studying the effect of multiple scattering on depth penetration in turbid media," Conference on Lasers and Electro-Optics, Optical Society of America, May 4-8, 1998, San Francisco, CA.

Boas D. A., "A fundamental limitation of linearized algorithms for diffuse optical tomography," OSA Topical Meeting on Advances in Photon Migration and Optical Imaging, Feb. 1998, Orlando, Fla.

Bizheva K., A. M. Siegel, and D. A. Boas, "Dynamic Low Coherence Interferometry as a tool for imaging and quantification of Brownian motion within highly scattering media," OSA Topical Meeting on Advances in Photon Migration and Optical Imaging, Feb. 1998, Orlando, Fla.

Siegel A. M., X. Cheng, M. Stankovic, and D. A. Boas, "The Boston DOTS: Development of a Diffuse Optical Tomography System,"OSA Topical Meeting on Advances in Photon Migration and Optical Imaging, Feb. 1998, Orlando, Fla.

Cheng X., M. Stankovic, P. Stubblefield, and D. A. Boas, "An investigation of the effects of layered tissue on NIR imaging of deep heterogeneous structure," OSA Topical Meeting on Advances in Photon Migration and Optical Imaging, Feb. 1998, Orlando, Fla.

Boas D. A., G. Nishimura, A. G. Yodh, K. T. Schomacker, and N. S. Nishioka, "Diffusing temporal light correlation for the diagnosis of tissue burns," SPIE/BioS West, Feb. 9-12, 1997, San Jose, CA.

Boas D. A., A. G. Yodh, K. T. Schomacker, and N. S. Nishioka, "Diagnosis of burn depth in tissues using diffusing temporal correlation," Conference on Lasers and Electro-Optics, June 3, 1996, Anaheim, CA.

Boas D. A., M. A. O'Leary, B. Chance, and A. G. Yodh, "Practical limits for the detection and characterization of optical inhomogeneities using diffuse photon density waves," Optical Society of America's Topical Meeting on Advances in Optical Imaging and Photon Migration, March 18, 1996, Orlando, FL.

Boas D. A., I. V. Meglinsky, L. E. Campbell, B. Chance, and A. G. Yodh, "Flow properties of heterogeneous turbid media probed by diffusing temporal correlation," Optical Society of America's Topical Meeting on Advances in Optical Imaging and Photon Migration, March 19, 1996, Orlando, FL.

Meglinsky I. V., D. A. Boas, B. Chance, and A. G. Yodh, "In vivo measurements of blood flow changes using diffusing wave correlation techniques," Optical Society of America's Topical Meeting on Advances in Optical Imaging and Photon Migration, March 20, 1996, Orlando, FL.

Liu H., D. A. Boas, A. G. Yodh, and B. Chance, "Influence of clear cerebrospinal fluid on NIR brain imaging and cerebral oxygenation monitoring," Optical Society of America's Topical Meeting on Advances in Optical Imaging and Photon Migration, March 20, 1996, Orlando, FL.

Boas D. A., I. V. Meglinsky, L. Zemany, L. E. Campbell, B. Chance, and A. G. Yodh, "Diffusion of temporal field correlation with selected applications," Biophysical Society's Annual Meeting, Feb. 1996, Baltimore, MD (poster presentation).

Boas D. A., L. E. Campbell, and A. G. Yodh, "Temporal fluctuation imaging of turbid media," Conference on Lasers and Electro-Optics, May 26, 1995, Baltimore, MD.

Boas D. A., M. A. O'Leary, B. Chance, and A. G. Yodh, "Limits to detecting and characterizating localized inhomogeneities with diffusing photons," Conference on Lasers and Electro-Optics, May 26, 1995, Baltimore, MD.

Boas D. A., L. E. Campbell, and A. G. Yodh, "Fluctuation imaging with diffusing-wave spectroscopy," American Physical Society's March Meeting, 1995, San Jose, CA.

Boas D. A., H. Liu, M. A. O'Leary, B. Chance, and A. G. Yodh, "Photon migration within the P3 approximation," SPIE/BioS West, Feb. 5-7, 1995, San Jose, CA.

Boas, D. A., L. E. Campbell, and A. G. Yodh, "Temporal fluctuation imaging of turbid media," SPIE/BioS West, Feb. 5-7, 1995, San Jose, CA.

Boas D. A., M. A. O'Leary, B. Chance, and A. G. Yodh, "Limits to detecting and characterizing localized inhomogeneities with diffuse photon density waves," Medical Optical Imaging Symposium, Dec. 2, 1994, Philadelphia, PA.

Boas D. A., M. A. O'Leary, B. Chance, A. G. Yodh, "Scattering of diffuse photon density waves by spherical objects," Conference on Lasers and Electro-Optics, May 1994, Anaheim, CA.

Boas D. A., M. A. O'Leary, B. Chance, A. G. Yodh, "Scattering of diffuse photon density waves from spherical inhomogeneities embedded in random media," American Physical Society's March Meeting, 1994, Pittsburgh, PA.

O'Leary M. A., D. A. Boas, B. Chance, and A. G. Yodh, "Imaging turbid media with diffuse photon density waves," American Physical Society's March Meeting, 1994, Pittsburgh, PA.

Boas D. A., M. A. O'Leary, B. Chance, and A. G. Yodh, "Scattering and Reradiation of diffuse photon density waves by spherical inhomogeneites," Conference on Lasers and Electro-Optics, May 1993, Baltimore, MD (poster presentation).

Boas D. A., M. A. O'Leary, B. Chance, and A. G. Yodh, "Refraction and diffraction of diffuse photon density waves," Biophysics Annual Conference, Feb 1993, Washington, D.C.

Society Affiliations

American Physical Society
American Association for the Advancement of Science
Biophysical Society
International Society of Magnetic Resonance in Medicine
Optical Society of America
SPIE