2024 Publications

• Shiroishi MS, Erickson BJ, Hu LS, Barboriak DP, Becerra L, Bell LC, Boss MA, Boxerman JL, Cen S, Cimino L, Fan Z, Keenan KE, Kirsch JE, Ameli N, Nazemi S, Quarles CC, Rosen MA, Rodriguez Jr L, Schmainda KM, Zahlmann G, Zhou Y, Obuchowski N, Wu O. The QIBA Profile for Dynamic Susceptibility Contrast MRI-Based Quantitative Imaging Biomarkers for Assessing Gliomas. Radiology. 2024 Dec;313(3):e232555. doi: 10.1148/radiol.232555. PMID: 39656118.
• Deng A, Xu H, Gaynor BJ, Cole JW, Giese AK, Schirmer MD, McArdle PF, Mitchell BD, Wu O, Rost NS, Kittner SJ; MRI-GENIE Investigators. The association of SUR1 polymorphisms with acute infarct size: The MRI-GENIE study. J Stroke Cerebrovasc Dis. 2024 Nov 1;34(1):108109. doi: 10.1016/j.jstrokecerebrovasdis.2024.108109. Epub ahead of print. PMID: 39489406.
• Presciutti AM, Siry-Bove B, Parker RA, Wu O, Elmer J, Donnino MW, Perman SM, Vranceanu AM. Thematic analysis of cardiac arrest survivors' and their caregivers' psychosocial intervention needs. Gen Hosp Psychiatry. 2024 Oct 22:S0163-8343(24)00220-2. doi: 10.1016/j.genhosppsych.2024.10.015. Epub ahead of print. PMID: 39462752.
• Bonkhoff AK, Cohen AL, Drew W, Ferguson MA, Hussain A, Lin C, Schaper FLWVJ, Bourached A, Giese AK, Oliveira LC, Regenhardt RW, Schirmer MD, Jern C, Lindgren AG, Maguire J, Wu O, Zafar S, Rhee JY, Kimchi EY, Corbetta M, Rost NS, Fox MD; MRI‐GENIE and GISCOME Investigators and the International Stroke Genetics Consortium. Prediction of stroke severity: systematic evaluation of lesion representations. Ann Clin Transl Neurol. 2024 Oct 11. doi: 10.1002/acn3.52215. Epub ahead of print. PMID: 39394714.
• Presciutti AM, Elmer J, Donnino MW, Wu O, Parker RA, Perman SM, Vranceanu AM. Preventing chronic distress in cardiac arrest survivors and their caregivers: Perspectives of multidisciplinary healthcare professionals. Gen Hosp Psychiatry. 2024 Sep 21:S0163-8343(24)00200-7. doi: 10.1016/j.genhosppsych.2024.09.011. Epub ahead of print. PMID: 39341731.
• Wang Z, Yang Y, Chen Y, Yuan T, Sermesant M, Delingette H, Wu O. Mutual Information Guided Diffusion for Zero-shot Cross-modality Medical Image Translation. IEEE Trans Med Imaging. 2024 Mar 29;PP. doi: 10.1109/TMI.2024.3382043. Epub ahead of print. PMID: 38551825.
• Cougo P, Colares H, Farinhas JG, Hämmerle M, Neves P, Bezerra R, Balduino A, Wu O, Pontes-Neto OM. Subtle white matter intensity changes on fluid-attenuated inversion recovery imaging in patients with ischaemic stroke. Brain Commun. 2024 Mar 13;6(2):fcae089. doi: 10.1093/braincomms/fcae089. PMID: 38529359; PMCID: PMC10963121.
• Kamogawa N, Miwa K, Toyoda K, Jensen M, Inoue M, Yoshimura S, Fukuda-Doi M, Kitazono T, Boutitie F, Ma H, Ringleb P, Wu O, Schwamm LH, Warach S, Hacke W, Davis SM, Donnan GA, Gerloff C, Thomalla G, Koga M; Evaluation of Unknown Onset Stroke Thrombolysis Trials (EOS) Investigators. Thrombolysis for Wake-Up Stroke Versus Non-Wake-Up Unwitnessed Stroke: EOS Individual Patient Data Meta-Analysis. Stroke. 2024 Apr;55(4):895-904. doi: 10.1161/STROKEAHA.123.043358. Epub 2024 Mar 8. PMID: 38456303; PMCID: PMC10978262.
• Bourached A, Bonkhoff AK, Schirmer MD, Regenhardt RW, Bretzner M, Hong S, Dalca AV, Giese AK, Winzeck S, Jern C, Lindgren AG, Maguire J, Wu O, Rhee J, Kimchi EY, Rost NS. Scaling behaviours of deep learning and linear algorithms for the prediction of stroke severity. Brain Commun. 2024 Jan 10;6(1):fcae007. doi: 10.1093/braincomms/fcae007. PMID: 38274570; PMCID: PMC10808016.

2023 Publications

• Filippi CG, Stein JM, Wang Z, Bakas S, Liu Y, Chang PD, Lui Y, Hess C, Barboriak DP, Flanders AE, Wintermark M, Zaharchuk G, Wu O. Ethical Considerations and Fairness in the Use of Artificial Intelligence for Neuroradiology. AJNR Am J Neuroradiol. 2023 Aug 31. doi: 10.3174/ajnr.A7963. Epub ahead of print. PMID: 37652578.
• Brusaferri L, Alshelh Z, Schnieders JH, Sandström A, Mohammadian M, Morrissey EJ, Kim M, Chane CA, Grmek GC, Murphy JP, Bialobrzewski J, DiPietro A, Klinke J, Zhang Y, Torrado-Carvajal A, Mercaldo N, Akeju O, Wu O, Rosen BR, Napadow V, Hadjikhani N, Loggia ML. Neuroimmune activation and increased brain aging in chronic pain patients after the COVID-19 pandemic onset. Brain Behav Immun. 2024 Feb;116:259-266. doi: 10.1016/j.bbi.2023.12.016. Epub 2023 Dec 9. PMID: 38081435; PMCID: PMC10872439.
• Franx AA, van Tilborg G, Taha A, Bobi J, van der Toorn A, van Heijningen C, van Beusekom H, Wu O, Dijkhuizen RM. Hyperperfusion profiles after recanalization differentially predict outcome in a rat ischemic stroke model. J Cereb Blood Flow Metab. 2024 Feb;44(2):209-223. doi: 10.1177/0271678X231208993. Epub 2023 Oct 24. PMID: 37873758; PMCID: PMC10993873.
• Shiroishi MS, Weinert D, Cen SY, Varghese B, Dondlinger T, Prah M, Mendoza J, Nazemi S, Ameli N, Amini N, Shoas S, Chen S, Bigjahan B, Zada G, Chen T, Neman-Ebrahim J, Chang EL, Chow F, Fan Z, Yang W, Attenello FJ, Ye J, Kim PE, Patel VN, Lerner A, Acharya J, Hu LS, Quarles CC, Boxerman JL, Wu O, Schmainda KM. A Cross-Sectional Study to Test Equivalence of Low-versus Intermediate-Flip Angle Dynamic Susceptibility Contrast MRI Measures of Relative Cerebral Blood Volume in Patients with High-Grade Gliomas at 1.5 Tesla Field Strength. Front Oncol. 2023 Sep 20;13:1156843. doi: 10.3389/fonc.2023.1156843. PMID: 37799462; PMCID: PMC10548232.
• Amorim E, Zheng WL, Jing J, Ghassemi MM, Lee JW, Wu O, Herman S, Pang T, Sivaraju A, Gaspard N, Hirsch LJ, Ruijter BJ, Tjepkema-Cloostermans MC, Hofmeijer J,. van Putten MJAM, Westover MG. Neurophysiology State Dynamics Underlying Acute Neurological Recovery After Cardiac Arrest. Neurology. 2023 Aug 29;101(9):e940-e952. doi: 10.1212/WNL.0000000000207537. Epub 2023 Jul 6. PMID: 37414565; PMCID: PMC10501085.
• Schaper FLWVJ, Nordberg J, Cohen AL, Lin C, Hsu J, Horn A, Ferguson MA, Siddiqi SH, Drew W, Soussand L, Winkler AM, Simó M, Bruna J, Rheims S, Guenot M, Bucci M, Nummenmaa L, Staals J, Colon AJ, Ackermans L, Bubrick EJ, Peters JM, Wu O, Rost NS, Grafman J, Blumenfeld H, Temel Y, Rouhl RPW, Joutsa J, Fox MD. Mapping Lesion-Related Epilepsy to a Human Brain Network. JAMA Neurol. 2023 Jul 3:e231988. doi: 10.1001/jamaneurol.2023.1988. Epub ahead of print. PMID: 37399040; PMCID: PMC10318550.
• Dhaynaut M, Grashow R, Normandin M, Wu O, Marengi D Jr, Terry D, Sanchez J, Weisskopf M, Speizer F, Taylor H, Guehl N, Seshadri S, Beiser A, Daneshvar D, Johnson K, Iverson GL, Zafonte RD, El Fakhri G, Baggish A. Tau Positron Emission Tomography and Neurocognitive Function Among Former Professional American-Style Football Players. J Neurotrauma. 2023 Jun 6. doi: 10.1089/neu.2022.0454. Epub ahead of print. PMID: 37282582.
• Dairi I, Brown C, DiGregorio H, Wasfy M, Baggish A, Pitler L, Copen WA, Doyle M, Wu O, Zafonte R, Tenforde AS. A Case Report of Reversible Cognitive Decline in a Former Professional American-Style Football Player: Findings from the Football Players Health Study In-Person Assessments. Curr Sports Med Rep. 2023 May 1;22(5):154-157. doi: 10.1249/JSR.0000000000001061. PMID: 37141607.
• Presciutti AM, Bannon SM, Yamin JB, Newman MM, Parker RA, Elmer J, Wu O, Donnino MW, Perman SM, Vranceanu AM. The relationship between mindfulness and enduring somatic threat severity in long-term cardiac arrest survivors. J Behav Med. 2023 Mar 9:1–7. doi: 10.1007/s10865-023-00405-x. Epub ahead of print. PMID: 36892781; PMCID: PMC9995732
• Bretzner M, Bonkhoff AK, Schirmer MD, Hong S, Dalca A, Donahue K, Giese AK, Etherton MR, Rist PM, Nardin M, Regenhardt RW, Leclerc X, Lopes R, Gautherot M, Wang C, Benavente OR, Cole JW, Donatti A, Griessenauer C, Heitsch L, Holmegaard L, Jood K, Jimenez-Conde J, Kittner SJ, Lemmens R, Levi CR, McArdle PF, McDonough CW, Meschia JF, Phuah CL, Rolfs A, Ropele S, Rosand J, Roquer J, Rundek T, Sacco RL, Schmidt R, Sharma P, Slowik A, Sousa A, Stanne TM, Strbian D, Tatlisumak T, Thijs V, Vagal A, Wasselius J, Woo D, Wu O, Zand R, Worrall BB, Maguire J, Lindgren AG, Jern C, Golland P, Kuchcinski G, Rost NS. Radiomics-Derived Brain Age Predicts Functional Outcome After Acute Ischemic Stroke. Neurology, vol. 100, no. 8, pp. e822–e833, 2023, ISSN: 1526-632X.
• Bonkhoff AK, Schirmer MD, Bretzner M, Hong S, Regenhardt RW, Donahue KL, Nardin MJ, Dalca AV, Giese AK, Etherton MR, Hancock BL, Mocking SJT, McIntosh EC, Attia J, Cole JW, Donatti A, Griessenauer CJ, Heitsch L, Holmegaard L, Jood K, Jimenez-Conde J, Kittner SJ, Lemmens R, Levi CR, McDonough CW, Meschia JF, Phuah CL, Ropele S, Rosand J, Roquer J, Rundek T, Sacco RL, Schmidt R, Sharma P, Slowik A, Sousa A, Stanne TM, Strbian D, Tatlisumak T, Thijs V, Vagal A, Wasselius J, Woo D, Zand R, McArdle PF, Worrall BB, Jern C, Lindgren AG, Maguire J, Wu O, Rost NS; MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium. The relevance of rich club regions for functional outcome post-stroke is enhanced in women. Hum Brain Mapp, vol. 44, no. 4, pp. 1579–1592, 2023, ISSN: 1097-0193. PMID: 36440953

2022 Publications

• Kulpanowski AM, Copen WA, Hancock B, Rosenthal ES, Schoenfeld DA, Dodelson JA, Edlow BL, Kimberly WT, Amorim E, Westover MG, Ning M, Schaefer PW, Malhotra R, Giacino JT, Greer DM, Wu O. Severe Cerebral Edema in Substance-Related Cardiac Arrest Patients [Internet]. Resuscitation 2022; Publisher's VersionAbstract
• Bonkhoff AK, Ullberg T, Bretzner M, Hong S, Schirmer MD, Regenhardt RW, Donahue KL, Nardin MJ, Dalca AV, Giese AK, Etherton MR, Hancock BL, Mocking SJT, McIntosh EC, Attia J, Cole JW, Donatti A, Griessenauer CJ, Heitsch L, Holmegaard L, Jood K, Jimenez-Conde J, Kittner SJ, Lemmens R, Levi CR, McDonough CW, Meschia JF, Phuah CL, Ropele S, Rosand J, Roquer J, Rundek T, Sacco RL, Schmidt R, Sharma P, Slowik A, Sousa A, Stanne TM, Strbian D, Tatlisumak T, Thijs V, Vagal A, Woo D, Zand R, McArdle PF, Worrall BB, Jern C, Lindgren AG, Maguire J, Wu O, Frid P, Rost NS, Wasselius J. Deep profiling of multiple ischemic lesions in a large, multi-center cohort: Frequency, spatial distribution, and associations to clinical characteristics. Front Neurosci. 2022 Aug 25;16:994458. doi: 10.3389/fnins.2022.994458. eCollection 2022. PMID: 36090258
• Miwa M; Koga M; Jensen M; Inoue M; Yoshimura S; Fukuda-Doi M; Boutitie F; Ma H; Ringleb P; Wu O; Schwamm LH; Warach S; Hacke W; Davis SM; Donnan GA; Gerloff C; Thomalla G; Toyoda K, on behalf of Evaluation of unknown Onset Stroke thrombolysis trials (EOS) investigators. Alteplase for stroke with unknown onset time in chronic kidney disease: a pooled analysis of individual participant data. Stroke. 2022 Nov;53(11):3295-3303. doi: 10.1161/STROKEAHA.122.039086. Epub 2022 Aug 23. PMID: 35997023
• Bonkhoff AK, Hong S, Bretzner M, Schirmer MD, Regenhardt RW, Arsava EM, Donahue K, Nardin M, Dalca A, Giese AK, Etherton MR, Hancock BL, Mocking SJT, McIntosh E, Attia J, Benavente O, Cole JW, Donatti A, Griessenauer C, Heitsch L, Holmegaard L, Jood K, Jimenez-Conde J, Kittner S, Lemmens R, Levi C, McDonough CW, Meschia J, Phuah CL, Rolfs A, Ropele S, Rosand J, Roquer J, Rundek T, Sacco RL, Schmidt R, Sharma P, Slowik A, Soederholm M, Sousa A, Stanne TM, Strbian D, Tatlisumak T, Thijs V, Vagal A, Wasselius J, Woo D, Zand R, McArdle P, Worrall BB, Jern C, Lindgren AG, Maguire J, Golland P, Bzdok D, Wu O, Rost NS. Association of Stroke Lesion Pattern and White Matter Hyperintensity Burden With Stroke Severity and Outcome. Neurology. 2022 Sep 27;99(13):e1364-e1379. doi: 10.1212/WNL.0000000000200926. Epub 2022 Jul 8. PMID: 35803717; PMCID: PMC9576289.
• Frid P, Wasselius J, Drake M, Wu O, Petersson J, Rost NS, Lindgren A; MRI-GENIE study, the ISGC. Fetal posterior cerebral artery configurations in an ischemic stroke versus an unselected hospital population. Acta Neurol Scand. 2022 Mar;145(3):297-304.
• Bonkhoff AK, Bretzner M, Hong S, Schirmer MD, Cohen A, Regenhardt RW, Donahue KL, Nardin MJ, Dalca AV, Giese AK, Etherton MR, Hancock BL, Mocking SJT, McIntosh EC, Attia J, Benavente OR, Bevan S, Cole JW, Donatti A, Griessenauer CJ, Heitsch L, Holmegaard L, Jood K, Jimenez-Conde J, Kittner SJ, Lemmens R, Levi CR, McDonough CW, Meschia JF, Phuah CL, Rolfs A, Ropele S, Rosand J, Roquer J, Rundek T, Sacco RL, Schmidt R, Sharma P, Slowik A, Söderholm M, Sousa A, Stanne TM, Strbian D, Tatlisumak T, Thijs V, Vagal A, Wasselius J, Woo D, Zand R, McArdle PF, Worrall BB, Jern C, Lindgren AG, Maguire J, Fox MD, Bzdok D, Wu O, Rost NS; MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium. Sex-specific lesion pattern of functional outcomes after stroke. Brain Commun. 2022 Feb 2;4(2):fcac020.
• Zheng W-L, Amorim E, Jing J, Wu O, Ghassemi M, Lee JW, Sivaraju A, Pang T, Herman ST, Gaspard N, Ruijter BJ, Tjepkema-Cloostermans MC, Hofmeijer J, Putten MV, Westover B. Predicting Neurological Outcome from Electroencephalogram Dynamics in Comatose Patients after Cardiac Arrest with Deep Learning. IEEE Trans Biomed Eng, vol. 69, no. 5, pp. 1813–1825, 2022. Abstract

2021 Publications

• Simpkins AN, Tahsili-Fahadan P, Buchwald N, De Prey J, Farooqui A, Mugge LA, Ranasinghe T, Senetar AJ, Echevarria FD, Alvi MM, Wu O. Adapting Clinical Practice of Thrombolysis for Acute Ischemic Stroke Beyond 4.5 Hours: A Review of the Literature. J Stroke Cerebrovasc Dis 2021;30(11):106059.Abstract
• Hong S, Giese A-K, Schirmer MD, Bonkhoff AK, Bretzner M, Rist P, Dalca AV, Regenhardt RW, Etherton MR, Donahue KL, Nardin M, Mocking SJT, McIntosh EC, Attia J, Benavente OR, Cole JW, Donatti A, Griessenauer CJ, Heitsch L, Holmegaard L, Jood K, Jimenez-Conde J, Roquer J, Kittner SJ, Lemmens R, Levi CR, McDonough CW, Meschia JF, Phuah C-L, Rolfs A, Ropele S, Rosand J, Rundek T, Sacco RL, Schmidt R, Enzinger C, Sharma P, Slowik A, Sousa A, Stanne TM, Strbian D, Tatlisumak T, Thijs V, Vagal A, Wasselius J, Woo D, Zand R, McArdle PF, Worrall BB, Wu O, Jern C, Lindgren AG, Maguire J, Tomppo L, Golland P, Rost NS. Excessive White Matter Hyperintensity Increases Susceptibility to Poor Functional Outcomes After Acute Ischemic Stroke. Front Neurol 2021;12:700616.Abstract
• Etherton MR, Schirmer MD, Zotin MCZ, Rist PM, Boulouis G, Lauer A, Wu O, Rost NS. Global white matter structural integrity mediates the effect of age on ischemic stroke outcomes. Int J Stroke 2021;:17474930211055906.Abstract
• Zheng W-L, Amorim E, Jing J, Ge W, Hong S, Wu O, Ghassemi M, Lee JW, Sivaraju A, Pang T, Herman ST, Gaspard N, Ruijter BJ, Sun J, Tjepkema-Cloostermans MC, Hofmeijer J, van Putten MJAM, Westover BM. Predicting neurological outcome in comatose patients after cardiac arrest with multiscale deep neural networks. Resuscitation 2021;169:86-94.Abstract
• Bonkhoff AK, Schirmer MD, Bretzner M, Etherton M, Donahue K, Tuozzo C, Nardin M, Giese A-K, Wu O, Calhoun VD, Grefkes C, Rost NS. Abnormal dynamic functional connectivity is linked to recovery after acute ischemic stroke. Hum Brain Mapp 2021;42(7):2278-2291.Abstract
• Bretzner M, Bonkhoff AK, Schirmer MD, Hong S, Dalca AV, Donahue KL, Giese A-K, Etherton MR, Rist PM, Nardin M, Marinescu R, Wang C, Regenhardt RW, Leclerc X, Lopes R, Benavente OR, Cole JW, Donatti A, Griessenauer CJ, Heitsch L, Holmegaard L, Jood K, Jimenez-Conde J, Kittner SJ, Lemmens R, Levi CR, McArdle PF, McDonough CW, Meschia JF, Phuah C-L, Rolfs A, Ropele S, Rosand J, Roquer J, Rundek T, Sacco RL, Schmidt R, Sharma P, Slowik A, Sousa A, Stanne TM, Strbian D, Tatlisumak T, Thijs V, Vagal A, Wasselius J, Woo D, Wu O, Zand R, Worrall BB, Maguire JM, Lindgren A, Jern C, Golland P, Kuchcinski G, Rost NS. MRI Radiomic Signature of White Matter Hyperintensities Is Associated With Clinical Phenotypes. Front Neurosci 2021;15:691244.Abstract
• Etherton MR, Wu O, Giese A-K, Rost NS. Normal-appearing white matter microstructural injury is associated with white matter hyperintensity burden in acute ischemic stroke. Int J Stroke 2021;16(2):184-191.Abstract
• Bonkhoff AK, Schirmer MD, Bretzner M, Hong S, Regenhardt RW, Brudfors M, Donahue KL, Nardin MJ, Dalca AV, Giese A-K, Etherton MR, Hancock BL, Mocking SJT, McIntosh EC, Attia J, Benavente OR, Bevan S, Cole JW, Donatti A, Griessenauer CJ, Heitsch L, Holmegaard L, Jood K, Jimenez-Conde J, Kittner SJ, Lemmens R, Levi CR, McDonough CW, Meschia JF, Phuah C-L, Rolfs A, Ropele S, Rosand J, Roquer J, Rundek T, Sacco RL, Schmidt R, Sharma P, Slowik A, Söderholm M, Sousa A, Stanne TM, Strbian D, Tatlisumak T, Thijs V, Vagal A, Wasselius J, Woo D, Zand R, McArdle PF, Worrall BB, Jern C, Lindgren AG, Maguire J, Bzdok D, Wu O, Rost NS. Outcome after acute ischemic stroke is linked to sex-specific lesion patterns. Nat Commun 2021;12(1):3289.Abstract

2020 Publications

• Schirmer MD, Donahue KL, Nardin MJ, Dalca AV, Giese A-K, Etherton MR, Mocking SJT, McIntosh EC, Cole JW, Holmegaard L, Jood K, Jimenez-Conde J, Kittner SJ, Lemmens R, Meschia JF, Rosand J, Roquer J, Rundek T, Sacco RL, Schmidt R, Sharma P, Slowik A, Stanne TM, Vagal A, Wasselius J, Woo D, Bevan S, Heitsch L, Phuah C-L, Strbian D, Tatlisumak T, Levi CR, Attia J, McArdle PF, Worrall BB, Wu O, Jern C, Lindgren A, Maguire J, Thijs V, Rost NS. Brain Volume: An Important Determinant of Functional Outcome After Acute Ischemic Stroke. Mayo Clin Proc 2020;95(5):955-965.Abstract
• Drake M, Frid P, Hansen BM, Wu O, Giese A-K, Schirmer MD, Donahue K, Cloonan L, Irie RE, Bouts MJRJ, McIntosh EC, Mocking SJT, Dalca AV, Sridharan R, Xu H, Giralt-Steinhauer E, Holmegaard L, Jood K, Roquer J, Cole JW, McArdle PF, Broderick JP, Jiménez-Conde J, Jern C, Kissela BM, Kleindorfer DO, Lemmens R, Meschia JF, Rundek T, Sacco RL, Schmidt R, Sharma P, Slowik A, Thijs V, Woo D, Worrall BB, Kittner SJ, Mitchell BD, Rosand J, Golland P, Lindgren A, Rost NS, Wassélius J. Diffusion-Weighted Imaging, MR Angiography, and Baseline Data in a Systematic Multicenter Analysis of 3,301 MRI Scans of Ischemic Stroke Patients-Neuroradiological Review Within the MRI-GENIE Study. Front Neurol 2020;11:577.Abstract
• González GR, Silva GS, He J, Sadaghiani S, Wu O, Singhal AB. Identifying Severe Stroke Patients Likely to Benefit From Thrombectomy Despite Delays of up to a Day. Sci Rep 2020;10(1):4008.Abstract
• Dubost F, de Bruijne M, Nardin M, Dalca AV, Donahue KL, Giese A-K, Etherton MR, Wu O, de Groot M, Niessen W, Vernooij M, Rost NS, Schirmer MD. Multi-atlas image registration of clinical data with automated quality assessment using ventricle segmentation. Med Image Anal 2020;63:101698.Abstract
• Giese A-K, Schirmer MD, Dalca AV, Sridharan R, Donahue KL, Nardin M, Irie R, McIntosh EC, Mocking SJT, Xu H, Cole JW, Giralt-Steinhauer E, Jimenez-Conde J, Jern C, Kleindorfer DO, Lemmens R, Wasselius J, Lindgren A, Rundek T, Sacco RL, Schmidt R, Sharma P, Slowik A, Thijs V, Worrall BB, Woo D, Kittner SJ, McArdle PF, Mitchell BD, Rosand J, Meschia JF, Wu O, Golland P, Rost NS. White matter hyperintensity burden in acute stroke patients differs by ischemic stroke subtype. Neurology 2020;95(1):e79-e88.Abstract
• Etherton MR, Fotiadis P, Giese A-K, Iglesias JE, Wu O, Rost NS. White Matter Hyperintensity Burden Is Associated With Hippocampal Subfield Volume in Stroke. Front Neurol 2020;11:588883.Abstract
• Thomalla G, Boutitie F, Ma H, Koga M, Ringleb P, Schwamm LH, Wu O, Bendszus M, Bladin CF, Campbell BCV, Cheng B, Churilov L, Ebinger M, Endres M, Fiebach JB, Fukuda-Doi M, Inoue M, Kleinig TJ, Latour LL, Lemmens R, Levi CR, Leys D, Miwa K, Molina CA, Muir KW, Nighoghossian N, Parsons MW, Pedraza S, Schellinger PD, Schwab S, Simonsen CZ, Song SS, Thijs V, Toni D, Hsu CY, Wahlgren N, Yamamoto H, Yassi N, Yoshimura S, Warach S, Hacke W, Toyoda K, Donnan GA, Davis SM, Gerloff C, of unknown thrombolysis trials investigators EOS (EOS). Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data. Lancet 2020;396(10262):1574-1584.Abstract

2019 Publications

• Etherton MR, Wu O, Cougo P, Lorenzano S, Li H, Cloonan L, Bouts MJRJ, Lauer A, Arai K, Lo EH, Feske SK, Furie KL, Rost NS. Sex-specific differences in white matter microvascular integrity after ischaemic stroke. Stroke Vasc Neurol 2019;4(4):198-205.Abstract
• Wu O, Winzeck S, Giese A-K, Hancock BL, Etherton MR, Bouts MJRJ, Donahue K, Schirmer MD, Irie RE, Mocking SJT, McIntosh EC, Bezerra R, Kamnitsas K, Frid P, Wasselius J, Cole JW, Xu H, Holmegaard L, Jiménez-Conde J, Lemmens R, Lorentzen E, McArdle PF, Meschia JF, Roquer J, Rundek T, Sacco RL, Schmidt R, Sharma P, Slowik A, Stanne TM, Thijs V, Vagal A, Woo D, Bevan S, Kittner SJ, Mitchell BD, Rosand J, Worrall BB, Jern C, Lindgren AG, Maguire J, Rost NS. Big Data Approaches to Phenotyping Acute Ischemic Stroke Using Automated Lesion Segmentation of Multi-Center Magnetic Resonance Imaging Data. Stroke 2019;50(7):1734-1741.Abstract
• Ktena SI, Schirmer MD, Etherton MR, Giese A-K, Tuozzo C, Mills BB, Rueckert D, Wu O, Rost NS. Brain Connectivity Measures Improve Modeling of Functional Outcome After Acute Ischemic Stroke. Stroke 2019;50(10):2761-2767.Abstract
• Snider SB, Bodien YG, Bianciardi M, Brown EN, Wu O, Edlow BL. Disruption of the ascending arousal network in acute traumatic disorders of consciousness. Neurology 2019;93(13):e1281-e1287.Abstract
• Lorenzano S, Rost NS, Khan M, Li H, Batista LM, Chutinet A, Green RE, Thankachan TK, Thornell B, Muzikansky A, Arai K, Som AT, Pham L-DD, Wu O, Harris GJ, Lo EH, Blumberg JB, Milbury PE, Feske SK, Furie KL. Early molecular oxidative stress biomarkers of ischemic penumbra in acute stroke. Neurology 2019;93(13):e1288-e1298.Abstract
• Schirmer MD, Etherton Md PhD MR, Dalca PhD AV, Giese Md A-K, Cloonan MSc L, Wu PhD O, Golland PhD P, Rost Md Mph Faan NS. Effective Reserve: A Latent Variable to Improve Outcome Prediction in Stroke. J Stroke Cerebrovasc Dis 2019;28(1):63-69.Abstract
• Winzeck S, Mocking SJT, Bezerra R, Bouts MJRJ, McIntosh EC, Diwan I, Garg P, Chutinet A, Kimberly WT, Copen WA, Schaefer PW, Ay H, Singhal AB, Kamnitsas K, Glocker B, Sorensen AG, Wu O. Ensemble of Convolutional Neural Networks Improves Automated Segmentation of Acute Ischemic Lesions Using Multiparametric Diffusion-Weighted MRI. AJNR Am J Neuroradiol 2019;40(6):938-945.Abstract
• Rocha EA, Ji R, Ay H, Li Z, Arsava EM, Silva GS, Sorensen AG, Wu O, Singhal AB. Reduced Ischemic Lesion Growth with Heparin in Acute Ischemic Stroke. J Stroke Cerebrovasc Dis 2019;28(6):1500-1508.Abstract
• Schirmer MD, Ktena SI, Nardin MJ, Donahue KL, Giese A-K, Etherton MR, Wu O, Rost NS. Rich-Club Organization: An Important Determinant of Functional Outcome After Acute Ischemic Stroke. Front Neurol 2019;10:956.Abstract
• Schirmer MD, Giese A-K, Fotiadis P, Etherton MR, Cloonan L, Viswanathan A, Greenberg SM, Wu O, Rost NS. Spatial Signature of White Matter Hyperintensities in Stroke Patients. Front Neurol 2019;10:208.Abstract
• Mazwi NL, Izzy S, Tan CO, Martinez S, Glenn MB, Giacino JT, Wu O, Zafonte R, Edlow BL. Traumatic Microbleeds in the Hippocampus and Corpus Callosum Predict Duration of Posttraumatic Amnesia. J Head Trauma Rehabil 2019;34(6):E10-E18.Abstract
• Schirmer MD, Dalca AV, Sridharan R, Giese A-K, Donahue KL, Nardin MJ, Mocking SJT, McIntosh EC, Frid P, Wasselius J, Cole JW, Holmegaard L, Jern C, Jimenez-Conde J, Lemmens R, Lindgren AG, Meschia JF, Roquer J, Rundek T, Sacco RL, Schmidt R, Sharma P, Slowik A, Thijs V, Woo D, Vagal A, Xu H, Kittner SJ, McArdle PF, Mitchell BD, Rosand J, Worrall BB, Wu O, Golland P, Rost NS. White matter hyperintensity quantification in large-scale clinical acute ischemic stroke cohorts - The MRI-GENIE study. Neuroimage Clin 2019;23:101884.Abstract
• Etherton MR, Wu O, Giese A-K, Lauer A, Boulouis G, Mills B, Cloonan L, Donahue KL, Copen W, Schaefer P, Rost NS. White Matter Integrity and Early Outcomes After Acute Ischemic Stroke. Transl Stroke Res 2019;10(6):630-638.Abstract
• Chauhan G, Adams HHH, Satizabal CL, Bis JC, Teumer A, Sargurupremraj M, Hofer E, Trompet S, Hilal S, Smith AV, Jian X, Malik R, Traylor M, Pulit SL, Amouyel P, Mazoyer B, Zhu YC, Kaffashian S, Schilling S, Beecham GW, Montine TJ, Schellenberg GD, Kjartansson O, Guðnason V, Knopman DS, Griswold ME, Windham BG, Gottesman RF, Mosley TH, Schmidt R, Saba Y, Schmidt H, Takeuchi F, Yamaguchi S, Nabika T, Kato N, Rajan KB, Aggarwal NT, De Jager PL, Evans DA, Psaty BM, Rotter JI, Rice K, Lopez OL, Liao J, Chen C, Cheng CY, Wong TY, Ikram MK, van der Lee SJ, Amin N, Chouraki V, DeStefano AL, Aparicio HJ, Romero JR, Maillard P, DeCarli C, Wardlaw JM, Hernández MDCV, Luciano M, Liewald D, Deary IJ, Starr JM, Bastin ME, Muñoz Maniega S, Slagboom PE, Beekman M, Deelen J, Uh HW, Lemmens R, Brodaty H, Wright MJ, Ames D, Boncoraglio GB, Hopewell JC, Beecham AH, Blanton SH, Wright CB, Sacco RL, Wen W, Thalamuthu A, Armstrong NJ, Chong E, Schofield PR, Kwok JB, van der Grond J, Stott DJ, Ford I, Jukema JW, Vernooij MW, Hofman A, Uitterlinden AG, van der Lugt A, Wittfeld K, Grabe HJ, Hosten N, von Sarnowski B, Völker U, Levi C, Jimenez-Conde J, Sharma P, Sudlow CLM, Rosand J, Woo D, Cole JW, Meschia JF, Slowik A, Thijs V, Lindgren A, Melander O, Grewal RP, Rundek T, Rexrode K, Rothwell PM, Arnett DK, Jern C, Johnson JA, Benavente OR, Wasssertheil-Smoller S, Lee JM, Wong Q, Mitchell BD, Rich SS, McArdle PF, Geerlings MI, van der Graaf Y, de Bakker PIW, Asselbergs FW, Srikanth V, Thomson R, McWhirter R, Moran C, Callisaya M, Phan T, Rutten-Jacobs LCA, Bevan S, Tzourio C, Mather KA, Sachdev PS, van Duijn CM, Worrall BB, Dichgans M, Kittner SJ, Markus HS, Ikram MA, Fornage M, Launer LJ, Seshadri S, Longstreth WT Jr, Debette S; Stroke Genetics Network (SiGN), the International Stroke Genetics Consortium (ISGC), METASTROKE, Alzheimer's Disease Genetics Consortium (ADGC), and the Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting. Neurology. 2019 Jan 16. pii: 10.1212/WNL.0000000000006851. doi: 10.1212/WNL.0000000000006851.

2018 Publications

• Joutsa J, Shih LC, Horn A, Reich MM, Wu O, Rost NS, Fox MD. Identifying therapeutic targets from spontaneous beneficial brain lesions. Ann Neurol. 2018 Jul;84(1):153-157. doi: 10.1002/ana.25285.
• Threlkeld ZD, Bodien YG, Rosenthal ES, Giacino JT, Nieto-Castanon A, Wu O, Whitfield-Gabrieli S, Edlow BL.  Functional Networks Reemerge During Recovery of Consciousness after Acute Severe Traumatic Brain Injury. Cortex. 2018 Sep;106:299-308. doi: 10.1016/j.cortex.2018.05.004. Epub 2018 May 12.
• Wu O. Beyond lesion volumes: Network based approach for the investigation of neurocognitive deficits in chronic subcortical strokes. Radiology. 2018 May 8:180382. doi: 10.1148/radiol.2018180382. [Epub ahead of print].
• Etherton MR, Barreto AD,Schwamm LH, Wu O. Neuroimaging Paradigms to Identify Patients for Reperfusion Therapy in Stroke of Unknown Onset. Front. Neurol. 2018. 9:327. doi: 10.3389/fneur.2018.00327
• Schwamm LH*, Wu O*, Song S, Latour L, Ford A, Hsia A, Muzikansky A, Betensky R, Yoo AJ, Lev MH, Boulouis G, Lauer A, Cougo P, Copen WA, Harris GJ, Warach S. Intravenous Thrombolysis in Unwitnessed Stroke Onset: MR WITNESS Trial Results. Ann Neurol. 2018 Apr 24. doi: 10.1002/ana.25235. [Epub ahead of print]. *Authors Contributed Equally.
• Schroder J, Cheng B, Ebinger M, Kohrmann M, Wu O, Kang DW, Liebeskind DS, Tourdias T, Singer OC, Campbell B, Luby M, Warach S, Fiehler J, Kemmling A, Fiebach JB, Gerloff C, Thomalla G, on Behalf of the STIR and VISTA Imaging Investigators. Impact of Lesion Load Thresholds on Alberta Stroke Program Early Computed Tomographic Score in Diffusion-Weighted Imaging. Front Neurol. 2018. 9:273. doi: 10.3389/fneur.2018.00273.
• Edlow BL, Keene CD, Perl D, Iacono D, Folkerth R, Stewart W, MacDonald CL, Augustinack J, Diaz-Arrastia R, Estrada C, Flannery E, Gordon W, Grabowski T, Hansen K, Hoffman J, Kroenke C, Larson E, Lee P, Mareyam A, McNab JA, McPhee J, Moreau AL, Renz A, Richmire K, Stevens A, Tang CY, Tirrell LS, Trittschuh E, van der Kouwe A, Varjabedian A, Wald LL, Wu O, Yendiki A, Young L, Zollei L, Fischl B, Crane PK, Dams-O'Connor K. Multimodal Characterization of the Late Effects of TBI (LETBI): A Methodological Overview of the LETBI Project. J Neurotrauma. 2018 Feb 8. doi: 10.1089/neu.2017.5457. [Epub ahead of print]
• Lorenzano S, Rost NS, Khan M, Li H, Lima FO, Maas MB, Green RE, Thankachan TK, Dipietro AJ, Arai K, Som AT, Pham LD, Wu O, Harris GJ, Lo EH, Blumberg JB, Milbury PE, Feske SK, Furie KL. Oxidative Stress Biomarkers of Brain Damage: Hyperacute Plasma F2-Isoprostane Predicts Infarct Growth in Stroke. Stroke. 2018 Mar;49(3):630-637. doi: 10.1161/STROKEAHA.117.018440. Epub 2018 Jan 25.

   

2017 Publications

• Copen WA, Yoo AJ, Rost NS, Morais LT, Schaefer PW, González RG, Wu O. In patients with suspected acute stroke, CT perfusion-based cerebral blood flow maps cannot substitute for DWI in measuring the ischemic core. PLoS One. 2017 Nov 30;12(11):e0188891. doi: 10.1371/journal.pone.0188891. eCollection 2017
• Etherton MR, Wu O, Cougo P, Giese AK, Cloonan L, Fitzpatrick KM, Kanakis AS, Boulouis G, Karadeli HH, Lauer A, Rosand J, Furie KL, Rost NS. Structural Integrity of Normal Appearing White Matter and Sex-Specific Outcomes After Acute Ischemic Stroke. Stroke. 2017 Dec;48(12):3387-3389. doi: 10.1161/STROKEAHA.117.019258. Epub 2017 Nov 10.
• Edlow BL, Chatelle C, Spencer CA, Chu CJ, Bodien YG, O'Connor KL, Hirschberg RE, Hochberg LR, Giacino JT, Rosenthal ES, Wu O. Early detection of consciousness in patients with acute severe traumatic brain injury. Brain. 2017 Sep 1;140(9):2399-2414. doi: 10.1093/brain/awx176.
• Rannikmäe K, Sivakumaran V, Millar H, Malik R, Anderson CD, Chong M, Dave T, Falcone GJ, Fernandez-Cadenas I, Jimenez-Conde J, Lindgren A, Montaner J, O'Donnell M, Paré G, Radmanesh F, Rost NS, Slowik A, Söderholm M, Traylor M, Pulit SL, Seshadri S, Worrall BB, Woo D, Markus HS, Mitchell BD, Dichgans M, Rosand J, Sudlow CLM; Stroke Genetics Network (SiGN), METASTROKE Collaboration, and International Stroke Genetics Consortium (ISGC).COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls. Neurology. 2017 Oct 24;89(17):1829-1839. doi: 10.1212/WNL.0000000000004560. Epub 2017 Sep 27.
• Giese AK, Schirmer MD, Donahue KL, Cloonan L, Irie R, Winzeck S, Bouts MJRJ, McIntosh EC, Mocking SJ, Dalca AV, Sridharan R, Xu H, Frid P, Giralt-Steinhauer E, Holmegaard L, Roquer J, Wasselius J, Cole JW, McArdle PF, Broderick JP, Jimenez-Conde J, Jern C, Kissela BM, Kleindorfer DO, Lemmens R, Lindgren A, Meschia JF, Rundek T, Sacco RL, Schmidt R, Sharma P, Slowik A, Thijs V, Woo D, Worrall BB, Kittner SJ, Mitchell BD, Rosand J, Golland P, Wu O*, Rost NS*.Design and rationale for examining neuroimaging genetics in ischemic stroke: The MRI-GENIE study. Neurol Genet. 2017 Aug 24;3(5):e180. doi: 10.1212/NXG.0000000000000180. eCollection 2017 Oct. *Authors Contributed Equally.
• Donahue MJ, Achten E, Cogswell PM, De Leeuw FE, Derdeyn CP, Dijkhuizen RM, Fan AP, Ghaznawi R, Heit JJ, Ikram MA, Jezzard P, Jordan LC, Jouvent E, Knutsson L, Leigh R, Liebeskind DS, Lin W, Okell TW, Qureshi AI, Stagg CJ, van Osch MJ, van Zijl PC, Watchmaker JM, Wintermark M, Wu O, Zaharchuk G, Zhou J, Hendrikse J. Consensus statement on current and emerging methods for the diagnosis and evaluation of cerebrovascular disease. J Cereb Blood Flow Metab. 2017 Jan 1:271678X17721830. doi: 10.1177/0271678X17721830. [Epub ahead of print]
• Rost NS, Cougo P, Lorenzano S, Li H, Cloonan L, Bouts MJ, Lauer A, Etherton MR, Karadeli HH, Musolino PL, Copen WA, Arai K, Lo EH, Feske SK, Furie KL, Wu O. Diffuse microvascular dysfunction and loss of white matter integrity predict poor outcomes in patients with acute ischemic stroke. J Cereb Blood Flow Metab. 2017 Jan 1:271678X17706449. doi: 10.1177/0271678X17706449. [Epub ahead of print]
• Izzy S, Mazwi NL, Martinez S, Spencer CA, Klein JP, Parikh G, Glenn MB, Greenberg SM, Greer DM, Wu O, Edlow BL. Revisiting Grade 3 Diffuse Axonal Injury: Not All Brainstem Microbleeds are Prognostically Equal. Neurocrit Care. 2017 May 5. doi: 10.1007/s12028-017-0399-2. [Epub ahead of print]
• Etherton MR, Wu O, Cougo P, Giese AK, Cloonan L, Fitzpatrick KM, Kanakis AS, Boulouis G, Karadeli HH, Lauer A, Rosand J, Furie KL, Rost NS. Integrity of normal-appearing white matter and functional outcomes after acute ischemic stroke. Neurology. 2017 May 2;88(18):1701-1708. doi: 10.1212/WNL.0000000000003890. Epub 2017 Apr 5.
• Etherton MR, Rost NS, Wu O. Infarct topography and functional outcomes. J Cereb Blood Flow Metab. 2017 Jan 1:271678X17700666. doi: 10.1177/0271678X17700666. [Epub ahead of print]
• Bouts MJ, Tiebosch IA, Rudrapatna US, van der Toorn A, Wu O, Dijkhuizen RM. Prediction of hemorrhagic transformation after experimental ischemic stroke using MRI-based algorithms. J Cereb Blood Flow Metab. 2017 Aug;37(8):3065-3076. doi: 10.1177/0271678X16683692. Epub 2016 Jan 1.
• Greer DM, Wu O. Neuroimaging in Cardiac Arrest Prognostication. Semin Neurol. 2017 Feb;37(1):66-74. doi: 10.1055/s-0036-1594253. Epub 2017 Feb 1.

   

2016 Publications

• Etherton MR, Wu O, Rost NS. Recent Advances in Leukoaraiosis: White Matter Structural Integrity and Functional Outcomes after Acute Ischemic Stroke. Curr Cardiol Rep. 2016 Dec;18(12):123.
• Warach SJ, Luby M, Albers GW, Bammer R, Bivard A, Campbell BC, Derdeyn C, Heit JJ, Khatri P, Lansberg MG, Liebeskind DS, Majoie CB, Marks MP, Menon BK, Muir KW, Parsons MW, Vagal A, Yoo AJ, Alexandrov AV, Baron JC, Fiorella DJ, Furlan AJ, Puig J, Schellinger PD, Wintermark M; Stroke Imaging Research (STIR) and VISTA-Imaging Investigators. Acute Stroke Imaging Research Roadmap III Imaging Selection and Outcomes in Acute Stroke Reperfusion Clinical Trials: Consensus Recommendations and Further Research Priorities. Stroke. 2016 May;47(5):1389-98. doi: 10.1161/STROKEAHA.115.012364. Epub 2016 Apr 12.
• Nelson S, Edlow BL, Wu O, Rosenthal ES, Westover MB, Rordorf G. Default Mode Network Perfusion in Aneurysmal Subarachnoid Hemorrhage. Neurocrit Care. 2016 Oct;25(2):237-42. doi: 10.1007/s12028-016-0244-z.
• Edlow BL, Copen WA, Izzy S, Bakhadirov K, van der Kouwe A, Glenn MB, Greenberg SM, Greer DM, Wu O. Diffusion tensor imaging in acute-to-subacute traumatic brain injury: a longitudinal analysis. BMC Neurol. 2016 Jan 11;16:2. doi: 10.1186/s12883-015-0525-8.
• NINDS Stroke Genetics Network (SiGN).; International Stroke Genetics Consortium (ISGC). Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study. Lancet Neurol. 2016 Feb;15(2):174-184. doi: 10.1016/S1474-4422(15)00338-5. Epub 2015 Dec 19.
• Edlow BL, Copen WA, Izzy S, van der Kouwe A, Glenn MB, Greenberg SM, Greer DM, Wu O. Longitudinal Diffusion Tensor Imaging Detects Recovery of Fractional Anisotropy Within Traumatic Axonal Injury Lesions. Neurocrit Care. 2016 Jun;24(3):342-52. doi: 10.1007/s12028-015-0216-8.

   

2015 Publications

• Bouts MJ, Westmoreland SV, de Crespigny AJ, Liu Y, Vangel M, Dijkhuizen RM, Wu O*, D'Arceuil HE*. Magnetic resonance imaging-based cerebral tissue classification reveals distinct spatiotemporal patterns of changes after stroke in non-human primates.BMC Neurosci. 2015 Dec 15;16:91. doi: 10.1186/s12868-015-0226-7. *Authors Contributed Equally.
• Kimberly WT, Battey TW, Wu O, Singhal AB, Campbell BC, Davis SM, Donnan GA, Sheth KN.Novel Imaging Markers of Ischemic Cerebral Edema and Its Association with Neurological Outcome. Acta Neurochir Suppl. 2016;121:223-6. doi: 10.1007/978-3-319-18497-5_40.
• Wu O, Cloonan L, Mocking SJT, Bouts MJRJ, Copen WA, Cougo-Pinto PT, Fitzpatrick K, Kanakis A, Schaefer PW, Rosand J, Furie KL, Rost NS. Role of acute lesion topography in initial stroke severity and long-term functional outcomes.Stroke. 2015;46(9):2438-44.DOI:10.1161/STROKEAHA.115.009643.
• Copen WA, Morais LT, Wu O, Schwamm LH, Schaefer PW,González RG, Yoo AJ. In Acute Stroke, Can CT Perfusion-Derived Cerebral Blood Volume Maps Substitute for Diffusion-Weighted Imaging in Identifying the Ischemic Core? PLoS One. 2015 Jul 20;10(7):e0133566. doi: 10.1371/journal.pone.0133566. http://www.ncbi.nlm.nih.gov/pubmed/26193486.
• Hirsch KG, Mlynash M, Eyngorn I, Pirsaheli R, Okada A, Komshian S, Chen C, Mayer SA, Meschia JF, Bernstein RA, Wu O, Greer DM, Wijman CA, Albers GW. Multi-center study of diffusion-weighted imaging in coma after cardiac arrest. Neurocrit Care. 2015 Jul 9. [Epub ahead of print] URL: http://www.ncbi.nlm.nih.gov/pubmed/26156112.
• Wintermark M, Luby M, Bornstein NM, Demchuk A, Fiehler J, Kudo K, Lees KR, Liebeskind DS, Michel P, Nogueira RG, Parsons MW, Sasaki M, Wardlaw JM, Wu O, Zhang W, Zhu G, Warach SJ. International survey of acute Stroke imaging used to make revascularization treatment decisions. Int J Stroke. 2015;10(5):759-62. URL: http://www.ncbi.nlm.nih.gov/pubmed/25833105.
• Schaefer PW, Pulli B, Copen WA, Hirsch JA, Leslie-Mazwi T, Schwamm LH, Wu O, Gonzalez RG, Yoo AJ. Combining MRI with NIHSS thresholds to predict outcome in acute ischemic stroke: value for patient selection. AJNR Am J Neuroradiol. 2015;36(2):259-64. URL: http://www.ncbi.nlm.nih.gov/pubmed/25258369.
• Jafari-Khouzani K, Emblem KE, Kalpathy-Cramer J, Bjornerud A, Vangel MG, Gerstner ER, Schmainda KM, Paynabar K, Wu O, Wen PY, Batchelor T, Rosen B, Stufflebeam SM. Repeatability of Cerebral Perfusion Using Dynamic Susceptibility Contrast MRI in Glioblastoma Patients. Translational oncology. 2015;8(3):137-46. URL: http://www.ncbi.nlm.nih.gov/pubmed/26055170.
• Copen WA, Deipolyi AR, Schaefer PW, Schwamm LH, Gonzalez RG, Wu O. Exposing hidden truncation-related errors in acute stroke perfusion imaging. AJNR Am J Neuroradiol. 2015;36(4):638-45. URL: http://www.ncbi.nlm.nih.gov/pubmed/25500309.
• Chu CJ, Tanaka N, Diaz J, Edlow BL, Wu O, Hamalainen M, Stufflebeam S, Cash SS, Kramer MA. EEG functional connectivity is partially predicted by underlying white matter connectivity. Neuroimage. 2015;108:23-33. PMCID: PMC4323839. URL: http://www.ncbi.nlm.nih.gov/pubmed/25534110.

   

2014 Publications

• Schroder J, Cheng B, Ebinger M, Kohrmann M, Wu O, Kang DW, Liebeskind DS, Tourdias T, Singer OC, Christensen S, Campbell B, Luby M, Warach S, Fiehler J, Fiebach JB, Gerloff C, Thomalla G, Stir, Investigators VI. Validity of acute stroke lesion volume estimation by diffusion-weighted imaging-Alberta Stroke Program Early Computed Tomographic Score depends on lesion location in 496 patients with middle cerebral artery stroke. Stroke. 2014;45(12):3583-8. URL: http://www.ncbi.nlm.nih.gov/pubmed/25316278.
• Kimberly WT, Battey TW, Pham L, Wu O, Yoo AJ, Furie KL, Singhal AB, Elm JJ, Stern BJ, Sheth KN. Glyburide is associated with attenuated vasogenic edema in stroke patients. Neurocrit Care. 2014;20(2):193-201. URL: http://www.ncbi.nlm.nih.gov/pubmed/24072459.
• Kamps MJ, Horn J, Oddo M, Fugate JE, Storm C, Cronberg T, Wu O, Binnekade JM, Hoedemaekers CW. Response to De Jonghe et al.: Prognostication of neurological outcome after cardiac arrest: standardization of neurological examination conditions is needed. Intensive Care Med. 2014;40(2):295. URL: http://www.ncbi.nlm.nih.gov/pubmed/24306085.
• Greer DM, Rosenthal ES, Wu O. Neuroprognostication of hypoxic-ischaemic coma in the therapeutic hypothermia era. Nat Rev Neurol. 2014;10(4):190-203. URL: http://www.ncbi.nlm.nih.gov/pubmed/24614515.
• Dalca AV, Sridharan R, Cloonan L, Fitzpatrick KM, Kanakis A, Furie KL, Rosand J, Wu O, Sabuncu M, Rost NS, Golland P. Segmentation of cerebrovascular pathologies in stroke patients with spatial and shape priors. Med Image Comput Comput Assist Interv. 2014;17(Pt 2):773-80. PMCID: PMC4260817. URL: http://www.ncbi.nlm.nih.gov/pubmed/25485450.
• Battey TW, Karki M, Singhal AB, Wu O, Sadaghiani S, Campbell BC, Davis SM, Donnan GA, Sheth KN, Kimberly WT. Brain edema predicts outcome after nonlacunar ischemic stroke. Stroke. 2014;45(12):3643-8. PMCID: PMC4295905. URL: http://www.ncbi.nlm.nih.gov/pubmed/25336512.
• Auriel E, Edlow BL, Reijmer YD, Fotiadis P, Ramirez-Martinez S, Ni J, Reed AK, Vashkevich A, Schwab K, Rosand J, Viswanathan A, Wu O, Gurol ME, Greenberg SM. Microinfarct disruption of white matter structure: a longitudinal diffusion tensor analysis. Neurology. 2014;83(2):182-8. PMCID: PMC4117171. URL: http://www.ncbi.nlm.nih.gov/pubmed/24920857.
• Wintermark M, Albers GW, Broderick JP, Demchuk AM, Fiebach JB, Fiehler J, Grotta JC, Houser G, Jovin TG, Lees KR, Lev MH, Liebeskind DS, Luby M, Muir KW, Parsons MW, von Kummer R, Wardlaw JM, Wu O, Yoo AJ, Alexandrov AV, Alger JR, Aviv RI, Bammer R, Baron JC, Calamante F, Campbell BC, Carpenter TC, Christensen S, Copen WA, Derdeyn CP, Haley EC, Jr., Khatri P, Kudo K, Lansberg MG, Latour LL, Lee TY, Leigh R, Lin W, Lyden P, Mair G, Menon BK, Michel P, Mikulik R, Nogueira RG, Ostergaard L, Pedraza S, Riedel CH, Rowley HA, Sanelli PC, Sasaki M, Saver JL, Schaefer PW, Schellinger PD, Tsivgoulis G, Wechsler LR, White PM, Zaharchuk G, Zaidat OO, Davis SM, Donnan GA, Furlan AJ, Hacke W, Kang DW, Kidwell C, Thijs VN, Thomalla G, Warach SJ, Stroke Imaging R, Virtual International Stroke Trials Archive -Imaging I. Acute Stroke Imaging Research Roadmap II. Stroke. 2013;44(9):2628-39. PMCID: PMC4040226. URL: http://www.ncbi.nlm.nih.gov/pubmed/23860298.

   

2013 Publications

• Sridharan R, Dalca AV, Fitzpatrick KM, Cloonan L, Kanakis A, Wu O, Furie KL, Rosand J, Rost NS, Golland P. Quantification and Analysis of Large Multimodal Clinical Image Studies: Application to Stroke. Multimodal Brain Image Anal (2013). 2013;8159:18-30. PMCID: PMC4306599. URL: http://www.ncbi.nlm.nih.gov/pubmed/25632408.
• Saver JL, Jovin TG, Smith WS, Albers GW, Baron JC, Boltze J, Broderick JP, Davis LA, Demchuk AM, DeSena S, Fiehler J, Gorelick PB, Hacke W, Holt B, Jahan R, Jing H, Khatri P, Kidwell CS, Lees KR, Lev MH, Liebeskind DS, Luby M, Lyden P, Megerian JT, Mocco J, Muir KW, Rowley HA, Ruedy RM, Savitz SI, Sipelis VJ, Shimp SK, 3rd, Wechsler LR, Wintermark M, Wu O, Yavagal DR, Yoo AJ, Consortium SV. Stroke treatment academic industry roundtable: research priorities in the assessment of neurothrombectomy devices. Stroke. 2013;44(12):3596-601. PMCID: PMC4142766. URL: http://www.ncbi.nlm.nih.gov/pubmed/24193797.
• Rowley J, Fonov V, Wu O, Eskildsen SF, Schoemaker D, Wu L, Mohades S, Shin M, Sziklas V, Cheewakriengkrai L, Shmuel A, Dagher A, Gauthier S, Rosa-Neto P, Alzheimer's Disease Neuroimaging I. White matter abnormalities and structural hippocampal disconnections in amnestic mild cognitive impairment and Alzheimer's disease. PLoS One. 2013;8(9):e74776. PMCID: PMC3785512. URL: http://www.ncbi.nlm.nih.gov/pubmed/24086371.
• Meschia JF, Arnett DK, Ay H, Brown RD, Jr., Benavente OR, Cole JW, de Bakker PI, Dichgans M, Doheny KF, Fornage M, Grewal RP, Gwinn K, Jern C, Conde JJ, Johnson JA, Jood K, Laurie CC, Lee JM, Lindgren A, Markus HS, McArdle PF, McClure LA, Mitchell BD, Schmidt R, Rexrode KM, Rich SS, Rosand J, Rothwell PM, Rundek T, Sacco RL, Sharma P, Shuldiner AR, Slowik A, Wassertheil-Smoller S, Sudlow C, Thijs VN, Woo D, Worrall BB, Wu O, Kittner SJ, Study NS. Stroke Genetics Network (SiGN) study: design and rationale for a genome-wide association study of ischemic stroke subtypes. Stroke. 2013;44(10):2694-702. PMCID: PMC4056331. URL: http://www.ncbi.nlm.nih.gov/pubmed/24021684.
• Kamps MJ, Horn J, Oddo M, Fugate JE, Storm C, Cronberg T, Wijman CA, Wu O, Binnekade JM, Hoedemaekers CW. Prognostication of neurologic outcome in cardiac arrest patients after mild therapeutic hypothermia: a meta-analysis of the current literature. Intensive Care Med. 2013;39(10):1671-82. URL: http://www.ncbi.nlm.nih.gov/pubmed/23801384.
• Greer DM, Yang J, Scripko PD, Sims JR, Cash S, Wu O, Hafler JP, Schoenfeld DA, Furie KL. Clinical examination for prognostication in comatose cardiac arrest patients. Resuscitation. 2013;84(11):1546-51. PMCID: PMC4041075. URL: http://www.ncbi.nlm.nih.gov/pubmed/23954666.
• Greer DM, Scripko PD, Wu O, Edlow BL, Bartscher J, Sims JR, Camargo EE, Singhal AB, Furie KL. Hippocampal magnetic resonance imaging abnormalities in cardiac arrest are associated with poor outcome. J Stroke Cerebrovasc Dis. 2013;22(7):899-905. URL: http://www.ncbi.nlm.nih.gov/pubmed/22995378.
• Edlow BL, Haynes RL, Takahashi E, Klein JP, Cummings P, Benner T, Greer DM, Greenberg SM, Wu O, Kinney HC, Folkerth RD. Disconnection of the ascending arousal system in traumatic coma. J Neuropathol Exp Neurol. 2013;72(6):505-23. PMCID: PMC3761353. URL: http://www.ncbi.nlm.nih.gov/pubmed/23656993.
• Edlow BL, Giacino JT, Wu O. Functional MRI and outcome in traumatic coma. Curr Neurol Neurosci Rep. 2013;13(9):375. PMCID: PMC3811121. URL: http://www.ncbi.nlm.nih.gov/pubmed/23881623.
• Edlow BL*, Giacino JT*, Hirschberg RE, Gerrard J, Wu O**, Hochberg LR**. Unexpected recovery of function after severe traumatic brain injury: the limits of early neuroimaging-based outcome prediction. Neurocrit Care. 2013;19(3):364-75. *,**Authors Contributed Equally. PMCID: PMC3902071. URL: http://www.ncbi.nlm.nih.gov/pubmed/23860665.
• Cheng B, Brinkmann M, Forkert ND, Treszl A, Ebinger M, Kohrmann M, Wu O, Kang DW, Liebeskind DS, Tourdias T, Singer OC, Christensen S, Luby M, Warach S, Fiehler J, Fiebach JB, Gerloff C, Thomalla G, Stir, Investigators VI. Quantitative measurements of relative fluid-attenuated inversion recovery (FLAIR) signal intensities in acute stroke for the prediction of time from symptom onset. J Cereb Blood Flow Metab. 2013;33(1):76-84. PMCID: PMC3965287. URL: http://www.ncbi.nlm.nih.gov/pubmed/23047272.
• Bouts MJ, Tiebosch IA, van der Toorn A, Viergever MA, Wu O, Dijkhuizen RM. Early identification of potentially salvageable tissue with MRI-based predictive algorithms after experimental ischemic stroke. J Cereb Blood Flow Metab. 2013;33(7):1075-82. PMCID: PMC3705436. URL: http://www.ncbi.nlm.nih.gov/pubmed/23571283.

   

2012 Publications

• Wu O, Lu J, Mandeville JB, Murata Y, Egi Y, Dai G, Marota JJ, Diwan I, Dijkhuizen RM, Kwong KK, Lo EH, Singhal AB. Dynamic functional cerebral blood volume responses to normobaric hyperoxia in acute ischemic stroke. J Cereb Blood Flow Metab. 2012;32(9):1800-9. PMCID: PMC3434635. URL: http://www.ncbi.nlm.nih.gov/pubmed/22739619.
• Wu O, Benner T, Roccatagliata L, Zhu M, Schaefer PW, Sorensen AG, Singhal AB. Evaluating effects of normobaric oxygen therapy in acute stroke with MRI-based predictive models. Med Gas Res. 2012;2(1):5. PMCID: PMC3388462. URL: http://www.ncbi.nlm.nih.gov/pubmed/22404875.
• Song SS, Latour LL, Ritter CH, Wu O, Tighiouart M, Hernandez DA, Ku KD, Luby M, Warach S. A pragmatic approach using magnetic resonance imaging to treat ischemic strokes of unknown onset time in a thrombolytic trial. Stroke. 2012;43(9):2331-5. PMCID: PMC3464959. URL: http://www.ncbi.nlm.nih.gov/pubmed/22693129.
• Greer DM, Yang J, Scripko PD, Sims JR, Cash S, Kilbride R, Wu O, Hafler JP, Schoenfeld DA, Furie KL. Clinical examination for outcome prediction in nontraumatic coma. Crit Care Med. 2012;40(4):1150-6. URL: http://www.ncbi.nlm.nih.gov/pubmed/22020245.
• Edlow BL, Wu O. Advanced neuroimaging in traumatic brain injury. Semin Neurol. 2012;32(4):374-400. PMCID: PMC3779469. URL: http://www.ncbi.nlm.nih.gov/pubmed/23361483.
• Edlow BL, Takahashi E, Wu O, Benner T, Dai G, Bu L, Grant PE, Greer DM, Greenberg SM, Kinney HC, Folkerth RD. Neuroanatomic connectivity of the human ascending arousal system critical to consciousness and its disorders. J Neuropathol Exp Neurol. 2012;71(6):531-46. PMCID: PMC3387430. URL: http://www.ncbi.nlm.nih.gov/pubmed/22592840.
• Deipolyi AR, Wu O, Macklin EA, Schaefer PW, Schwamm LH, Gilberto Gonzalez R, Copen WA. Reliability of cerebral blood volume maps as a substitute for diffusion-weighted imaging in acute ischemic stroke. J Magn Reson Imaging. 2012;36(5):1083-7. PMCID: PMC4110961. URL: http://www.ncbi.nlm.nih.gov/pubmed/22761110.
• Cheng B, Ebinger M, Kufner A, Kohrmann M, Wu O, Kang DW, Liebeskind D, Tourdias T, Singer OC, Christensen S, Warach S, Luby M, Fiebach JB, Fiehler J, Gerloff C, Thomalla G, Stroke Imaging Repository I. Hyperintense vessels on acute stroke fluid-attenuated inversion recovery imaging: associations with clinical and other MRI findings. Stroke. 2012;43(11):2957-61. PMCID: PMC3495102. URL: http://www.ncbi.nlm.nih.gov/pubmed/22933582.
• Arkink EB, Bleeker EJ, Schmitz N, Schoonman GG, Wu O, Ferrari MD, van Buchem MA, van Osch MJ, Kruit MC. Cerebral perfusion changes in migraineurs: a voxelwise comparison of interictal dynamic susceptibility contrast MRI measurements. Cephalalgia. 2012;32(4):279-88. PMCID: PMC3743424. URL: http://www.ncbi.nlm.nih.gov/pubmed/22290556.

   

2011 Publications

• Wu O, Schwamm LH, Sorensen AG. Imaging stroke patients with unclear onset times. Neuroimaging Clin N Am. 2011;21(2):327-44, xi. PMCID: PMC3109317. URL: http://www.ncbi.nlm.nih.gov/pubmed/21640303.
• Wu O, Batista LM, Lima FO, Vangel MG, Furie KL, Greer DM. Predicting clinical outcome in comatose cardiac arrest patients using early noncontrast computed tomography. Stroke. 2011;42(4):985-92. PMCID: PMC3107844. URL: http://www.ncbi.nlm.nih.gov/pubmed/21330629.
• Thomalla G, Cheng B, Ebinger M, Hao Q, Tourdias T, Wu O, Kim JS, Breuer L, Singer OC, Warach S, Christensen S, Treszl A, Forkert ND, Galinovic I, Rosenkranz M, Engelhorn T, Kohrmann M, Endres M, Kang DW, Dousset V, Sorensen AG, Liebeskind DS, Fiebach JB, Fiehler J, Gerloff C, Stir, Investigators VI. DWI-FLAIR mismatch for the identification of patients with acute ischaemic stroke within 4.5 h of symptom onset (PRE-FLAIR): a multicentre observational study. Lancet Neurol. 2011;10(11):978-86. URL: http://www.ncbi.nlm.nih.gov/pubmed/21978972.
• Kwong KK, Wu O, Chan ST, Nelissen K, Kholodov M, Chesler DA. Early time points perfusion imaging: relative time of arrival, maximum derivatives and fractional derivatives. Neuroimage. 2011;57(3):979-90. PMCID: PMC3129483. URL: http://www.ncbi.nlm.nih.gov/pubmed/21600995.
• Kwong KK, Reese TG, Nelissen K, Wu O, Chan ST, Benner T, Mandeville JB, Foley M, Vanduffel W, Chesler DA. Early time points perfusion imaging. Neuroimage. 2011;54(2):1070-82. PMCID: PMC2997123. URL: http://www.ncbi.nlm.nih.gov/pubmed/20851196.
• Gokcay F, Arsava EM, Baykaner T, Vangel M, Garg P, Wu O, Singhal AB, Furie KL, Sorensen AG, Ay H. Age-dependent susceptibility to infarct growth in women. Stroke. 2011;42(4):947-51. PMCID: PMC3066257. URL: http://www.ncbi.nlm.nih.gov/pubmed/21311058.
• Copen WA, Schaefer PW, Wu O. MR perfusion imaging in acute ischemic stroke. Neuroimaging Clin N Am. 2011;21(2):259-83, x. PMCID: PMC3135980. URL: http://www.ncbi.nlm.nih.gov/pubmed/21640299.

   

1997 - 2010 Publications

• Wu O, Dijkhuizen RM, Sorensen AG. Multiparametric magnetic resonance imaging of brain disorders. Top Magn Reson Imaging. 2010;21(2):129-38. PMCID: PMC3319343. URL: http://www.ncbi.nlm.nih.gov/pubmed/21613877.
• Emmer BJ, van Osch MJ, Wu O, Steup-Beekman GM, Steens SC, Huizinga TW, van Buchem MA, van der Grond J. Perfusion MRI in neuro-psychiatric systemic lupus erthemathosus. J Magn Reson Imaging. 2010;32(2):283-8. URL: http://www.ncbi.nlm.nih.gov/pubmed/20677252.
• Wu O, Sorensen AG, Benner T, Singhal AB, Furie KL, Greer DM. Comatose patients with cardiac arrest: predicting clinical outcome with diffusion-weighted MR imaging. Radiology. 2009;252(1):173-81. PMCID: PMC2702469. URL: http://www.ncbi.nlm.nih.gov/pubmed/19420318.
• Fujiwara N, Murata Y, Arai K, Egi Y, Lu J, Wu O, Singhal AB, Lo EH. Combination therapy with normobaric oxygen (NBO) plus thrombolysis in experimental ischemic stroke. BMC Neurosci. 2009;10:79. PMCID: PMC2714858. URL: http://www.ncbi.nlm.nih.gov/pubmed/19604385.
• Copen WA, Rezai Gharai L, Barak ER, Schwamm LH, Wu O, Kamalian S, Gonzalez RG, Schaefer PW. Existence of the diffusion-perfusion mismatch within 24 hours after onset of acute stroke: dependence on proximal arterial occlusion. Radiology. 2009;250(3):878-86. URL: http://www.ncbi.nlm.nih.gov/pubmed/19164120.
• Christensen S, Mouridsen K, Wu O, Hjort N, Karstoft H, Thomalla G, Rother J, Fiehler J, Kucinski T, Ostergaard L. Comparison of 10 perfusion MRI parameters in 97 sub-6-hour stroke patients using voxel-based receiver operating characteristics analysis. Stroke. 2009;40(6):2055-61. URL: http://www.ncbi.nlm.nih.gov/pubmed/19359626.
• Wintermark M, Albers GW, Alexandrov AV, Alger JR, Bammer R, Baron JC, Davis S, Demaerschalk BM, Derdeyn CP, Donnan GA, Eastwood JD, Fiebach JB, Fisher M, Furie KL, Goldmakher GV, Hacke W, Kidwell CS, Kloska SP, Kohrmann M, Koroshetz W, Lee TY, Lees KR, Lev MH, Liebeskind DS, Ostergaard L, Powers WJ, Provenzale J, Schellinger P, Silbergleit R, Sorensen AG, Wardlaw J, Wu O, Warach S. Acute stroke imaging research roadmap. AJNR Am J Neuroradiol. 2008;29(5):e23-30. PMCID: PMC2716734. URL: http://www.ncbi.nlm.nih.gov/pubmed/18477656.
• Wintermark M, Albers GW, Alexandrov AV, Alger JR, Bammer R, Baron JC, Davis S, Demaerschalk BM, Derdeyn CP, Donnan GA, Eastwood JD, Fiebach JB, Fisher M, Furie KL, Goldmakher GV, Hacke W, Kidwell CS, Kloska SP, Kohrmann M, Koroshetz W, Lee TY, Lees KR, Lev MH, Liebeskind DS, Ostergaard L, Powers WJ, Provenzale J, Schellinger P, Silbergleit R, Sorensen AG, Wardlaw J, Wu O, Warach S. Acute stroke imaging research roadmap. Stroke. 2008;39(5):1621-8. URL: http://www.ncbi.nlm.nih.gov/pubmed/18403743.
• van der Zijden JP, Bouts MJ, Wu O, Roeling TA, Bleys RL, van der Toorn A, Dijkhuizen RM. Manganese-enhanced MRI of brain plasticity in relation to functional recovery after experimental stroke. J Cereb Blood Flow Metab. 2008;28(4):832-40. URL: http://www.ncbi.nlm.nih.gov/pubmed/17987047.
• Hjort N, Wu O, Ashkanian M, Solling C, Mouridsen K, Christensen S, Gyldensted C, Andersen G, Ostergaard L. MRI detection of early blood-brain barrier disruption: parenchymal enhancement predicts focal hemorrhagic transformation after thrombolysis. Stroke. 2008;39(3):1025-8. URL: http://www.ncbi.nlm.nih.gov/pubmed/18258832.
• Christensen S, Calamante F, Hjort N, Wu O, Blankholm AD, Desmond P, Davis S, Ostergaard L. Inferring origin of vascular supply from tracer arrival timing patterns using bolus tracking MRI. J Magn Reson Imaging. 2008;27(6):1371-81. URL: http://www.ncbi.nlm.nih.gov/pubmed/18504757.
• Ay H, Arsava EM, Vangel M, Oner B, Zhu M, Wu O, Singhal A, Koroshetz WJ, Sorensen AG. Interexaminer difference in infarct volume measurements on MRI: a source of variance in stroke research. Stroke. 2008;39(4):1171-6. URL: http://www.ncbi.nlm.nih.gov/pubmed/18292377.
• Ay H, Arsava EM, Rosand J, Furie KL, Singhal AB, Schaefer PW, Wu O, Gonzalez RG, Koroshetz WJ, Sorensen AG. Severity of leukoaraiosis and susceptibility to infarct growth in acute stroke. Stroke. 2008;39(5):1409-13. URL: http://www.ncbi.nlm.nih.gov/pubmed/18340093.
• Wu O, Sumii T, Asahi M, Sasamata M, Ostergaard L, Rosen BR, Lo EH, Dijkhuizen RM. Infarct prediction and treatment assessment with MRI-based algorithms in experimental stroke models. J Cereb Blood Flow Metab. 2007;27(1):196-204. URL: http://www.ncbi.nlm.nih.gov/pubmed/16685257.
• van der Zijden JP, Wu O, van der Toorn A, Roeling TP, Bleys RL, Dijkhuizen RM. Changes in neuronal connectivity after stroke in rats as studied by serial manganese-enhanced MRI. Neuroimage. 2007;34(4):1650-7. URL: http://www.ncbi.nlm.nih.gov/pubmed/17175175.
• Makris N, Papadimitriou GM, van der Kouwe A, Kennedy DN, Hodge SM, Dale AM, Benner T, Wald LL, Wu O, Tuch DS, Caviness VS, Moore TL, Killiany RJ, Moss MB, Rosene DL. Frontal connections and cognitive changes in normal aging rhesus monkeys: a DTI study. Neurobiol Aging. 2007;28(10):1556-67. URL: http://www.ncbi.nlm.nih.gov/pubmed/16962214.
• Wu O, Christensen S, Hjort N, Dijkhuizen RM, Kucinski T, Fiehler J, Thomalla G, Rother J, Ostergaard L. Characterizing physiological heterogeneity of infarction risk in acute human ischaemic stroke using MRI. Brain. 2006;129(Pt 9):2384-93. URL: http://www.ncbi.nlm.nih.gov/pubmed/16891322.
• Wu O, Ostergaard L, Sorensen AG. Technical aspects of perfusion-weighted imaging. Neuroimaging Clin N Am. 2005;15(3):623-37, xi. URL: http://www.ncbi.nlm.nih.gov/pubmed/16360593.
• Hjort N, Christensen S, Solling C, Ashkanian M, Wu O, Rohl L, Gyldensted C, Andersen G, Ostergaard L. Ischemic injury detected by diffusion imaging 11 minutes after stroke. Ann Neurol. 2005;58(3):462-5. URL: http://www.ncbi.nlm.nih.gov/pubmed/16130095.
• Gottrup C, Thomsen K, Locht P, Wu O, Sorensen AG, Koroshetz WJ, Ostergaard L. Applying instance-based techniques to prediction of final outcome in acute stroke. Artif Intell Med. 2005;33(3):223-36. URL: http://www.ncbi.nlm.nih.gov/pubmed/15811787.
• Ay H, Koroshetz WJ, Benner T, Vangel MG, Wu O, Schwamm LH, Sorensen AG. Transient ischemic attack with infarction: a unique syndrome? Ann Neurol. 2005;57(5):679-86. URL: http://www.ncbi.nlm.nih.gov/pubmed/15852402.
• van Eijsden P, Notenboom RG, Wu O, de Graan PN, van Nieuwenhuizen O, Nicolay K, Braun KP. In vivo 1H magnetic resonance spectroscopy, T2-weighted and diffusion-weighted MRI during lithium-pilocarpine-induced status epilepticus in the rat. Brain Res. 2004;1030(1):11-8. URL: http://www.ncbi.nlm.nih.gov/pubmed/15567333.
• Ozsunar Y, Grant PE, Huisman TA, Schaefer PW, Wu O, Sorensen AG, Koroshetz WJ, Gonzalez RG. Evolution of water diffusion and anisotropy in hyperacute stroke: significant correlation between fractional anisotropy and T2. AJNR Am J Neuroradiol. 2004;25(5):699-705. URL: http://www.ncbi.nlm.nih.gov/pubmed/15140707.
• Huisman TA, Schwamm LH, Schaefer PW, Koroshetz WJ, Shetty-Alva N, Ozsunar Y, Wu O, Sorensen AG. Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury. AJNR Am J Neuroradiol. 2004;25(3):370-6. URL: http://www.ncbi.nlm.nih.gov/pubmed/15037457.
• Wu O, Ostergaard L, Weisskoff RM, Benner T, Rosen BR, Sorensen AG. Tracer arrival timing-insensitive technique for estimating flow in MR perfusion-weighted imaging using singular value decomposition with a block-circulant deconvolution matrix. Magn Reson Med. 2003;50(1):164-74. URL: http://www.ncbi.nlm.nih.gov/pubmed/12815691.
• Wu O, Ostergaard L, Koroshetz WJ, Schwamm LH, O'Donnell J, Schaefer PW, Rosen BR, Weisskoff RM, Sorensen AG. Effects of tracer arrival time on flow estimates in MR perfusion-weighted imaging. Magn Reson Med. 2003;50(4):856-64. URL: http://www.ncbi.nlm.nih.gov/pubmed/14523973.
• van Osch MJ, Vonken EJ, Wu O, Viergever MA, van der Grond J, Bakker CJ. Model of the human vasculature for studying the influence of contrast injection speed on cerebral perfusion MRI. Magn Reson Med. 2003;50(3):614-22. URL: http://www.ncbi.nlm.nih.gov/pubmed/12939770.
• Dijkhuizen RM, Singhal AB, Mandeville JB, Wu O, Halpern EF, Finklestein SP, Rosen BR, Lo EH. Correlation between brain reorganization, ischemic damage, and neurologic status after transient focal cerebral ischemia in rats: a functional magnetic resonance imaging study. J Neurosci. 2003;23(2):510-7. URL: http://www.ncbi.nlm.nih.gov/pubmed/12533611.
• Yamada K, Wu O, Gonzalez RG, Bakker D, Ostergaard L, Copen WA, Weisskoff RM, Rosen BR, Yagi K, Nishimura T, Sorensen AG. Magnetic resonance perfusion-weighted imaging of acute cerebral infarction: effect of the calculation methods and underlying vasculopathy. Stroke. 2002;33(1):87-94. URL: http://www.ncbi.nlm.nih.gov/pubmed/11779894.
• Schaefer PW, Romero JM, Grant PE, Wu O, Sorensen AG, Koroshetz W, Gonzalez RG. Perfusion magnetic resonance imaging of acute ischemic stroke. Semin Roentgenol. 2002;37(3):230-6. URL: http://www.ncbi.nlm.nih.gov/pubmed/12226902.
• Schaefer PW, Romero JM, Grant PE, Wu O, Sorensen AG, Koroshetz W, Gonzalez RG. Diffusion magnetic resonance imaging of acute ischemic stroke. Semin Roentgenol. 2002;37(3):219-29. URL: http://www.ncbi.nlm.nih.gov/pubmed/12226901.
• Dijkhuizen RM, Asahi M, Wu O, Rosen BR, Lo EH. Rapid breakdown of microvascular barriers and subsequent hemorrhagic transformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model. Stroke. 2002;33(8):2100-4. URL: http://www.ncbi.nlm.nih.gov/pubmed/12154270.
• Yoshiura T, Wu O, Zaheer A, Reese TG, Sorensen AG. Highly diffusion-sensitized MRI of brain: dissociation of gray and white matter. Magn Reson Med. 2001;45(5):734-40. URL: http://www.ncbi.nlm.nih.gov/pubmed/11323798.
• Wu O, Koroshetz WJ, Ostergaard L, Buonanno FS, Copen WA, Gonzalez RG, Rordorf G, Rosen BR, Schwamm LH, Weisskoff RM, Sorensen AG. Predicting tissue outcome in acute human cerebral ischemia using combined diffusion- and perfusion-weighted MR imaging. Stroke. 2001;32(4):933-42. URL: http://www.ncbi.nlm.nih.gov/pubmed/11283394.
• Hadjikhani N, Sanchez Del Rio M, Wu O, Schwartz D, Bakker D, Fischl B, Kwong KK, Cutrer FM, Rosen BR, Tootell RB, Sorensen AG, Moskowitz MA. Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci U S A. 2001;98(8):4687-92. PMCID: PMC31895. URL: http://www.ncbi.nlm.nih.gov/pubmed/11287655.
• Grant PE, He J, Halpern EF, Wu O, Schaefer PW, Schwamm LH, Budzik RF, Sorensen AG, Koroshetz WJ, Gonzalez RG. Frequency and clinical context of decreased apparent diffusion coefficient reversal in the human brain. Radiology. 2001;221(1):43-50. URL: http://www.ncbi.nlm.nih.gov/pubmed/11568319.
• Dijkhuizen RM, Ren J, Mandeville JB, Wu O, Ozdag FM, Moskowitz MA, Rosen BR, Finklestein SP. Functional magnetic resonance imaging of reorganization in rat brain after stroke. Proc Natl Acad Sci U S A. 2001;98(22):12766-71. PMCID: PMC60128. URL: http://www.ncbi.nlm.nih.gov/pubmed/11606760.
• Dijkhuizen RM, Asahi M, Wu O, Rosen BR, Lo EH. Delayed rt-PA treatment in a rat embolic stroke model: diagnosis and prognosis of ischemic injury and hemorrhagic transformation with magnetic resonance imaging. J Cereb Blood Flow Metab. 2001;21(8):964-71. URL: http://www.ncbi.nlm.nih.gov/pubmed/11487732.
• Copen WA, Schwamm LH, Gonzalez RG, Wu O, Harmath CB, Schaefer PW, Koroshetz WJ, Sorensen AG. Ischemic stroke: effects of etiology and patient age on the time course of the core apparent diffusion coefficient. Radiology. 2001;221(1):27-34. URL: http://www.ncbi.nlm.nih.gov/pubmed/11568317.
• Ostergaard L, Sorensen AG, Chesler DA, Weisskoff RM, Koroshetz WJ, Wu O, Gyldensted C, Rosen BR. Combined diffusion-weighted and perfusion-weighted flow heterogeneity magnetic resonance imaging in acute stroke. Stroke. 2000;31(5):1097-103. URL: http://www.ncbi.nlm.nih.gov/pubmed/10797171.
• Yoshiura T, Wu O, Sorensen AG. Advanced MR techniques: diffusion MR imaging, perfusion MR imaging, and spectroscopy. Neuroimaging Clin N Am. 1999;9(3):439-53. URL: http://www.ncbi.nlm.nih.gov/pubmed/10433637.
• Sorensen AG, Wu O, Copen WA, Davis TL, Gonzalez RG, Koroshetz WJ, Reese TG, Rosen BR, Wedeen VJ, Weisskoff RM. Human acute cerebral ischemia: detection of changes in water diffusion anisotropy by using MR imaging. Radiology. 1999;212(3):785-92. URL: http://www.ncbi.nlm.nih.gov/pubmed/10478247.
• Sanchez del Rio M, Bakker D, Wu O, Agosti R, Mitsikostas DD, Ostergaard L, Wells WA, Rosen BR, Sorensen G, Moskowitz MA, Cutrer FM. Perfusion weighted imaging during migraine: spontaneous visual aura and headache. Cephalalgia. 1999;19(8):701-7. URL: http://www.ncbi.nlm.nih.gov/pubmed/10570723.
• Ay H, Buonanno FS, Rordorf G, Schaefer PW, Schwamm LH, Wu O, Gonzalez RG, Yamada K, Sorensen GA, Koroshetz WJ. Normal diffusion-weighted MRI during stroke-like deficits. Neurology. 1999;52(9):1784-92. URL: http://www.ncbi.nlm.nih.gov/pubmed/10371524.
• Makris N, Worth AJ, Sorensen AG, Papadimitriou GM, Wu O, Reese TG, Wedeen VJ, Davis TL, Stakes JW, Caviness VS, Kaplan E, Rosen BR, Pandya DN, Kennedy DN. Morphometry of in vivo human white matter association pathways with diffusion-weighted magnetic resonance imaging. Ann Neurol. 1997;42(6):951-62. URL: http://www.ncbi.nlm.nih.gov/pubmed/9403488.