Mental Illness and Neuroscience Discovery (MIND) Insitute:
Boston Site
Principal Investigator:
Bruce Rosen, MD PhD, Massachusetts General Hospital
Current Project Period:
1/1/2004 - 12/31/2005 (renewed annually since 1999)
The Mental Illness and Neuroscience Discovery (MIND) Institute was founded to advance the understanding of mental illness and mental disorders through the use of modern brain imaging techniques. It consists of neuroimaging scientists and medical research institutions including the Harvard University, University of Minnesota, the University of New Mexico, and Los Alamos National Laboratory, and collaborates with other imaging centers such as The University of Iowa and the National Institutes of Health.
The MIND Institute aims to develop functional brain imaging techniques that optimize the spatial and temporal coverage, accuracy, and resolution of functional indices of brain activity and to apply these improved neuroimaging techniques to explore the mind and brain to enhance the lives of people with mental illness. A major goal of the MIND Institute is to foster interactions and collaborations within and across the participating sites to share advances and pool resources to address crucial questions about the mechanisms and treatment of mental illness.
The MIND Institute Boston Site involves investigators from MGH, Harvard Medical School, Massachusetts Mental Health Center, Brockton VA, and McLean Hospital. The program consists of three core basic and clinical science projects, each with several subprojects and a multi-site clinical consortium. Three cores support the activities of these projects.
For more information on any particular project, contact Julie Goodman.
Boston Area Schizophrenia Group
The Boston Schizophrenia Group (BSG) unites a group of independent schizophrenia researchers from three different clinical sites (MGH, Massachusetts Mental Health Center, Brockton VA) in the area for neuroimaging studies at the Athinoula A. Martinos Center. The labs involved share a common goal, to illuminate the neurological underpinnings of schizophrenia and related psychiatric illnesses.
| Project |
Leader |
| Event-related fMRI study of transitive inference in Schizophrenia |
Stephan Heckers, MD, McLean Hospital |
| Use of linguistic and non-linguistic context in language comprehension in Schizophrenia |
Gina Kuperberg, MD, PhD, Dept. of Neurology, MGH |
| Spatiotemporal Dynamics of Context Processing in Schizophrenia |
Dara Manoach, PhD, Dept. of Radiology, MGH |
| Temporal Lobe Neocortical Abnormalities in Schizophrenia: A structural, functional and clinical perspective |
Robert McCarley, MD, Brockton VA Medical Center |
| Towards the Prevention of Schizophrenia: Neurobiological Studies of Families with Schizophrenia |
Larry Seidman, PhD, Massachusetts Mental Health Center |
| Auditory, Sensorimotor, and Language Area Mapping Using MEG with & without fMRI Contraints |
Steven Stufflebeam, MD, Dept of Radiology, MGH |
Multimodal Imaging of Cognitive Processes
| Project |
Leader |
| Contextual Predictions Facilitate Visual Cognition |
Moshe Bar, PhD, Dept Radiology, MGH |
| Visual responses to local stimuli |
Dalia Sharon, PhD |
| Comprehension of real-world events |
Caroline West, PhD |
Basic Science Research
| Project |
Leader |
| Spatial point spread function |
Joseph Mandeville, PhD |
| Figure-ground segmentation versus shape processing |
Wim Vanduffel, PhD |
| fMRI guided in-vivo tractography in monkeys |
David Tuch, PhD and Wim Vanduffel, PhD |
| Direct measurement of functional connectivity |
Wim Vanduffel, PhD |
Computational Core
| Project |
Leader |
| Data Analysis and Modeling |
Bruce Fischl, PhD |
Consortium Projects
| Project |
Leader |
| Clinical (Schizophrenia) Consortium |
Randy Gollub, MD, PhD |
| MEG Consortium |
Matti Hamalainen, PhD |
| Cytoarchitectonic MRI (cMRI) Consortium |
Christian Farrar, PhD |
| MR Spectroscopy (MRS) Consortium |
Bruce Jenkins, PhD and Larry Wald, PhD |
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