Discrete bimodal probes for thrombus imaging
Vertical Tabs
J Am Chem Soc
2012 Jul 4
134
26
10799-802
10.1021/ja3045635
Epub Date:
Wednesday, June 20, 2012
Journal Articles
PubMed ID:
22698259
Here we report a generalizable solid/solution-phase strategy for the synthesis of discrete bimodal fibrin-targeted imaging probes. A fibrin-specific peptide was conjugated with two distinct imaging reporters at the C- and N-termini. In vitro studies demonstrated retention of fibrin affinity and specificity. Imaging studies showed that these probes could detect fibrin over a wide range of probe concentrations by optical, magnetic resonance, and positron emission tomography imaging.
Year:
2012