Imaging small vessel-associated white matter changes in aging
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Neuroscience
2014 Sep 12
276
174-86
10.1016/j.neuroscience.2013.11.041
Epub Date:
Friday, December 6, 2013
Journal Articles
PubMed ID:
24316059
Alterations in cerebrovascular structure and function may underlie the most common age-associated cognitive, psychiatric, and neurological conditions presented by older adults. Although much remains to understand, existing research suggests several age-associated detrimental conditions may be mediated through sometimes subtle small vessel-induced damage to the cerebral white matter. Here we review a selected portion of the vast work that demonstrates links between changes in vascular and neural health as a function of advancing age, and how even changes in low-to-moderate risk individuals, potentially beginning early in the adult age-span, may have an important impact on functional status in late life.
Year:
2014