Regional cortical thinning in preclinical Huntington disease and its relationship to cognition
Vertical Tabs
Neurology
2005 Sep 13
65
5
745-7
10.1212/01.wnl.0000174432.87383.87
Journal Articles
PubMed ID:
16157910
The authors studied presymptomatic individuals with the Huntington disease (HD) mutation to determine whether cortical thinning was present. They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occurs during the preclinical stages of HD.
Year:
2005