[Brainmap]: Klaus Scheffler - Human Functional Brain Imaging at 9.4T: Can We Resolve Subcortical Responses?

Tuesday, October 3, 2017 - 11:00 to 12:00
Building 75, Room 1103

Klaus Scheffler, Department of High-Field Magnetic Resonance, Max Planck Institute for
Biological Cybernetics, Tuebingen, Germany


Imaging at 7T or 9.4T therefore opens the possibility to resolve structures far below the thickness of 2-3 mm of the human neocortex. Anatomical images with an isotropic resolution below 200 m have been obtained at 9.4T that clearly resolve subcortical structures such as the line of Gennari or subcortical units within the brain stem. Functional BOLD images acquired with gradient echo or spin echo methods, in principle, may offer the same spatial resolution as anatomical images. Therefore, the BOLD response from single cortical layers or other mesoscopic substructures might be resolved. This presentation analysis the neurovascular fingerprint of pass-band bSSFP. The formation of MR signal from water proton magnetization during a random walk through the neurovascular network is modeled using Monte Carlo simulations for artificial cylinders with different diameter and orientation, as well as for four different sets of neurovascular networks acquired from the mouse parietal cortex measured with two-photon laser scanning microscopy at 1 µm isotropic resolution. In addition, selected Monte Carlo simulations of GE and SE have been performed to serve as a comparison to pass band bSSFP.