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Synapse. 2009 Sep;63(9):764-72 doi: 10.1002/syn.20659.

Dopaminergic response to graded dopamine concentration elicited by four amphetamine doses

Ren J, Xu H, Choi JK, Jenkins BG, Chen YI.

Abstract

UNLABELLED: We studied the metabolic responses to different DA concentrations elicited by four doses of D-amphetamine (AMPH, 0, 0.25, 0.5, 1.0, or 3.0 mg/kg). We compared the degree of DA release (via microdialysis) with striatal cAMP activity and whole brain maps of cerebral blood volume (rCBV) changes (via pharmacological MRI, phMRI).
RESULTS: AMPH increased DA release in the caudate/putamen (CPu) and cAMP activity in the CPu, nucleus accumbens (NAc), and medial prefrontal cortex (mPFC) in a linear dose-dependent manner (P

PMID: 19484725
PubMed Entry
| MGH/HST Martinos Center for Biomedical Imaging

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