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Contrast Media Mol Imaging. 2012 Mar-Apr;7(2):276-9 doi: 10.1002/cmmi.490.

1H chemical shift magnetic resonance imaging probes with high sensitivity for multiplex imaging

Yang Y, Schühle DT, Dai G, Alford JK, Caravan P.

Abstract

Proton-based chemical shift imaging probes were encapsulated inside nano-carriers to increase the sensivitity of the reporters. Co-encapsulation with a relaxation agent results in improved sensitivity and suppresses background signals. Simultaneous imaging of different chemical shift reporters allows multiplexed detection.

PMID: 22434641
PubMed Entry
| MGH/HST Martinos Center for Biomedical Imaging

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