Eur J Radiol. 2006 Mar;57(3):390-5 doi: 10.1016/j.ejrad.2005.12.026. 2006 Jan 23.

Threshold-dependent variability of coronary artery calcification measurements -- implications for contrast-enhanced multi-detector row-computed tomography

Moselewski F, Ferencik M, Achenbach S, Abbara S, Cury RC, Booth SL, Jang IK, Brady TJ, Hoffmann U.

Abstract

INTRODUCTION: The present study investigated the threshold-dependent variability of coronary artery calcification (CAC) measurements and the potential to quantify CAC in contrast-enhanced multi-detector row-computed tomography (MDCT).
METHODS: We compared the mean CT attenuation of CAC to luminal contrast enhancement of the coronary arteries in 30 patients (n = 30) undergoing standard coronary contrast-enhanced spiral MDCT. The modified Agatston score [AS], calcified plaque volume [CV], and mineral mass [MM]) at four different thresholds (130, 200, 300, and 400 HU) were measured in 50 patients who underwent non-contrast-enhanced MDCT.
RESULTS: Mean CT attenuation of CAC was similar to the attenuation of the contrast-enhanced coronary lumen (CAC 297.1 +/- 68.7 HU versus 295 +/- 65 HU (p DISCUSSION: We demonstrated that CAC measurements are threshold dependent with MM measurements having significantly less variation than AS or CV. Due to the similarity of mean CT attenuation of CAC and the contrast-enhanced coronary lumen accurate quantification of CAC may be difficult in standard coronary contrast-enhanced spiral MDCT.

PMID: 16431067
PubMed Entry