Chem Commun (Camb). [Epub ahead of print]

Gadolinium-binding helix-turn-helix peptides: DNA-dependent MRI contrast agents

Caravan P, Greenwood JM, Welch JT, Franklin SJ.

Abstract

A de novo designed gadolinium metallopeptide was found to be a very efficient relaxation agent, with 100% increase in relaxivity upon binding to DNA.

PMID: 14594287