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Neurology. 1998 May;50(5):1357-65

1H NMR spectroscopy studies of Huntington's disease: correlations with CAG repeat numbers

Jenkins BG, Rosas HD, Chen YC, Makabe T, Myers R, MacDonald M, Rosen BR, Beal MF, Koroshetz WJ.

Abstract

Huntington's disease (HD) is the result of an expanded (CAG) repeat in a gene on chromosome 4. A consequence of the gene defect may be progressive impairment of energy metabolism. We previously showed increased occipital cortex lactate in HD using localized 1H spectroscopy. We have now extended these studies to show an almost threefold elevation in occipital cortex lactate in 31 HD patients as compared with 17 normal control subjects (p

PMID: 9595987
PubMed Entry
| MGH/HST Martinos Center for Biomedical Imaging

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