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ACS Nano. 2012 Oct 23;6(10):8468-83 doi: 10.1021/nn303929a. 2012 Sep 27.

The state of nanoparticle-based nanoscience and biotechnology: progress, promises, and challenges

Pelaz B, Jaber S, de Aberasturi DJ, Wulf V, Aida T, de la Fuente JM, Feldmann J, Gaub HE, Josephson L, Kagan CR, Kotov NA, Liz-Marzán LM, Mattoussi H, Mulvaney P, Murray CB, Rogach AL, Weiss PS, Willner I, Parak WJ.

Abstract

Colloidal nanoparticles (NPs) have become versatile building blocks in a wide variety of fields. Here, we discuss the state-of-the-art, current hot topics, and future directions based on the following aspects: narrow size-distribution NPs can exhibit protein-like properties; monodispersity of NPs is not always required; assembled NPs can exhibit collective behavior; NPs can be assembled one by one; there is more to be connected with NPs; NPs can be designed to be smart; surface-modified NPs can directly reach the cytosols of living cells.

PMID: 23016700
| MGH/HST Martinos Center for Biomedical Imaging

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