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Angew Chem Int Ed Engl. 2012 Jul 9;51(28):6904-7 doi: 10.1002/anie.201201661. 2012 Jun 08.

Fluorochrome-functionalized magnetic nanoparticles for high-sensitivity monitoring of the polymerase chain reaction by magnetic resonance

Alcantara D, Guo Y, Yuan H, Goergen CJ, Chen HH, Cho H, Sosnovik DE, Josephson L.

Abstract

Easy to find: magnetic nanoparticles bearing fluorochromes (red) that intercalate with DNA (green) form microaggregates with DNA generated by the polymerase chain reaction (PCR). These aggregates can be detected at low cycle numbers by magnetic resonance (MR).

PMID: 22684680
PubMed Entry
| MGH/HST Martinos Center for Biomedical Imaging

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