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Ophthalmic Res. 2002 Jul-Aug;34(4):241-50 doi: 63883.

MRI of blood volume and cellular uptake of superparamagnetic iron in an animal model of choroidal melanoma

Krause M, Kwong KK, Xiong J, Gragoudas ES, Young LH.

Abstract

Functional magnetic resonance imaging (MRI), using monocrystalline iron oxide nanoparticles (MION) as a new intravascular contrast agent, was adapted for a rabbit model of pigmented choroidal melanoma. Three-dimensionally spoiled gradient recalled sequences were used for the quantitative assessment of blood volume and cellular uptake. In all ocular tissues studied, MION reduced the T(2)-weighted signal intensity within 0.5 h and at 24 h (both p

PMID: 12297697
PubMed Entry
| MGH/HST Martinos Center for Biomedical Imaging

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