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Chem Commun (Camb). 2014 Dec 25;50(99):15792-5 doi: 10.1039/c4cc06029f. 2014 Nov 05.

Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease

Tian Y, Zhang X, Li Y, Shoup TM, Teng X, Elmaleh DR, Moore A, Ran C.

Abstract

In this report, we reasoned that non-covalent modification of amyloid beta (Aβ) by crown ethers could inhibit its aggregation. We demonstrated that PiB-C, a conjugate PiB and crown ether, could significantly reduce the aggregation in vitro. Additionally, two-photon imaging showed that PiB-C could efficiently label Aβ plaques and CAAs in AD mice.

PMID: 25372154
PubMed Entry
| MGH/HST Martinos Center for Biomedical Imaging

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