Neurolimbic Research Laboratory

Nouchine Hadjikhani

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Publications - Peer reviewed articles

1. Hadjikhani N, Roland PE. Cross-modal transfer of information between the tactile and the visual representations in the human brain: A positron emission tomographic study. J Neurosci. 1998;18(3):1072-84.

2. Tootell RB, Mendola JD, Hadjikhani NK, Ledden PJ, Liu AK, Reppas JB, Sereno MI, Dale AM. Functional analysis of V3A and related areas in human visual cortex. J Neurosci. 1997;17(18):7060-78.

3. Tootell RBH, Hadjikhani NK, Mendola JD, Marrett S, Dale AM. From retinotopy to recognition: fMRI in human visual cortex. Trends in Cognitive Sciences. 1998;1(2):174-183.

4. Tootell RB, Hadjikhani NK, Vanduffel W, Liu AK, Mendola JD, Sereno MI, Dale AM. Functional analysis of primary visual cortex (V1) in humans. Proc Natl Acad Sci U S A. 1998;95(3):811-7.

5. Tootell RB, Mendola JD, Hadjikhani NK, Liu AK, Dale AM. The representation of the ipsilateral visual field in human cerebral cortex. Proc Natl Acad Sci U S A. 1998;95(3):818-24.

6. Hadjikhani N, Liu AK, Dale AM, Cavanagh P, Tootell RB. Retinotopy and color sensitivity in human visual cortical area V8. Nat Neurosci. 1998;1(3):235-41.

7. Tootell RB, Hadjikhani N, Hall EK, Marrett S, Vanduffel W, Vaughan JT, Dale AM. The retinotopy of visual spatial attention. Neuron. 1998;21(6):1409-22.

8. Hadjikhani N, Tootell RB. Projection of rods and cones within human visual cortex. Hum Brain Mapp. 2000;9(1):55-63.

9. Tootell RB, Hadjikhani N. Attention - brains at work! Nat Neurosci. 2000;3(3):206-8.

10. Van Essen DC, Lewis JW, Drury HA, Hadjikhani N, Tootell RB, Bakircioglu M, Miller MI. Mapping visual cortex in monkeys and humans using surface-based atlases. Vision Res. 2001;41(10-11):1359-78.

11. Pellerin L, Sibson NR, Hadjikhani N, Hyder F. What you see is what you think--or is it? Trends Neurosci. 2001;24(2):71-2.

12. Sasaki Y, Hadjikhani N, Fischl B, Liu AK, Marrett S, Dale AM, Tootell RB, Marret S. Local and global attention are mapped retinotopically in human occipital cortex. Proc Natl Acad Sci U S A. 2001;98(4):2077-82.

13. Tootell RB, Hadjikhani N. Where is 'dorsal V4' in human visual cortex? Retinotopic, topographic and functional evidence. Cereb Cortex. 2001;11(4):298-311.

14. Hadjikhani N, Sanchez Del Rio M, Wu O, Schwartz D, Bakker D, Fischl B, Kwong KK, Cutrer FM, Rosen BR, Tootell RB, Sorensen AG, Moskowitz MA. Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci U S A. 2001;98(8):4687-92.

15. Bonmassar G, Hadjikhani N, Ives JR, Hinton D, Belliveau JW. Influence of EEG electrodes on the BOLD fMRI signal. Hum Brain Mapp. 2001;14(2):108-15.

16. Hadjikhani N, de Gelder B. Neural basis of prosopagnosia: an fMRI study. Hum Brain Mapp. 2002;16(3):176-82.

17. DaSilva AF, Tuch DS, Wiegell MR, Hadjikhani N. A primer on diffusion tensor imaging of anatomical substructures. Neurosurg Focus. 2003;15(1):E4.

18. de Gelder B, Frissen I, Barton J, Hadjikhani N. A modulatory role for facial expressions in prosopagnosia. Proc Natl Acad Sci U S A. 2003;100(22):13105-10.

19. de Gelder B, Hadjikhani N. Shakespeare on the brain, Vivaldi on the weather, and Darwin on docu-soap? Trends Cogn Sci. 2003;7(11):479-480.

20. Hadjikhani N, de Gelder B. Seeing fearful body expressions activates the fusiform cortex and amygdala. Curr Biol. 2003;13(24):2201-5.

21. Hadjikhani N, Chabris CF, Joseph RM, Clark J, McGrath L, Aharon I, Feczko E, Tager-Flusberg H, Harris GJ. Early visual cortex organization in autism: an fMRI study. Neuroreport. 2004;15(2):267-70.

22. Hadjikhani N, Joseph RM, Snyder J, Chabris CF, Clark J, Steele S, McGrath L, Vangel M, Aharon I, Feczko E, Harris GJ, Tager-Flusberg H. Activation of the fusiform gyrus when individuals with autism spectrum disorder view faces. Neuroimage. 2004;22(3):1141-50.

23. de Gelder B, Snyder J, Greve D, Gerard G, Hadjikhani N. Fear fosters flight: A mechanism for fear contagion when perceiving emotion expressed by a whole body. Proc Natl Acad Sci U S A. 2004;101(47):16701-6.

24. Hadjikhani N, Joseph RM, Snyder J, Tager-Flusberg H. Anatomical differences in mirror neurons system and social cognition network in autism. Cerebral Cortex. 2006;16:1276-1282 (epub 11/23/2005).

25. de Gelder B, Hadjikhani N. Nonconscious recognition of emotional body language. NeuroReport. 2006;17(6):583-586.

26. Hadjikhani N, Joseph RM, Snyder J, Tager-Flusberg H. Abnormal activation ofthe social brain during face perception in autism. Human Brain Mapping. 2007;28:441-449.

27. Granziera C, DaSilva AFM, Snyder J, Tuch D, Hadjikhani N. Anatomical alterations of the visual motion processing network in migraine with and without aura. PLoS Medicine. 2006;3(10) e402.

See comment: Goadsby P. The migrainous brain: what you see is not all you get? PLoS Medicine 2006;3(10) e404.

28. DaSilva AF, Granziera C, Snyder J, Tuch DS, Vincent M, Hadjikhani N. Interictal alterations of the trigeminal somatosensory pathway and PAG in migraine. Neuroreport 2007;18(4)301-305.

29. Vincent M, Hadjikhani N. The cerebellum and migraine. Headache 2007;47:820-833.

30. Whitcher B, Wisco JJ, Hadjikhani N, Tuch DS. Statistical Group Comparison of Diffusion Tensors via Multivariate Hypothesis Testing Magnetic Resonance in Medicine 2007;57:1065-1074.

31. Vincent M, Hadjikhani N. Migraine aura and related phenomena: beyond scotomata and scintillations. Cephalagia 2007;27(12):1368-1377.

32. DaSilva AF, Granziera C, Snyder J, Hadjikhani N. Thickening in the Somatosensory Cortex of Migraine Patients. Neurology 2007;69:1990-1995.

33. Hadjikhani N, Hoge R, Snyder J, de Gelder B. Pointing with the eyes: the role of gaze in communicating danger. Brain and Cognition 2008;68:1-8. DOI: 10.1016/j.bandc.2008.01.008

34. Hadjikhani N. Relevance of cortical thickness in migraine sufferers. Expert Rev. Neurotherapeutics 2008;8(3):327-329

35. Thakkar K, Polli F, Joseph R, Tuch D, Hadjikhani N, Barton J, Manoach D. Response monitoring, repetitive behavior, and anterior cingulate abnormalities in autism spectrum disorders. Brain 2008;131:2464-2478

36. Knaus T, Silver A, Lindgren K, Hadjikhani N, Tager-Flusberg H. fMRI activation during a language task in adolescents with autism spectrum disorder. The Journal of the International Neuropsychological Society 2008; 14(16):967-979

37. Kaaro J, Partonen T, Naik P, Hadjikhani N. Is migraine a lateralization defect? NeuroReport 2008;19(13)1351-1353

38. Hadjikhani N, Joseph RM, Maoach DS, Naik P, Snyder J, Dominick K, Hoge R, Van den Stock J, Tager-Flusberg H, de Gelder B. Body expressions of emotion do not trigger fear contation in autism. Soc Cogn Affect Neurosci 2009 Mar;4(1)70-8

39. Meeren HKM, Hadjikhani N, Ahlfors SP, Hämäläinen MS, de Gelder B. Early Category-Specific Cortical Activation Revealed by Visual Stimulus Inversion. PLoS ONE 2008;3(10): e3503. doi:10.1371/journal.pone.0003503

40. Hadjikhani N, Kveraga K, Naik P, Ahlfors S. Early activation of face-specific cortex by face-like objects. NeuroReport 2009,20:403-407

41. Dahlem M, Hadjikhani N. Migraine aura: retracting particle-like waves in weakly susceptible cortex. PLoSONE 2009 4(4):e5007. Epub 2009 Apr 1.

42. Granziera C, Schmahmann JD, Hadjikhani N, Heiko M, Meuli R, Wedeen VJ, Krueger G. Diffusion Spectrum imaging shows the structural basis of functional cerebellar circuits in the human cerebellum in vivo. PLoSONE 2009 ;4(4):e5101. Epub 2009 Apr 2

43. Hadjikhani N. Serotonin, pregnancy and increased autism prevalence: is there a link? Medical Hypotheses 2009, Dec 15 [epub ahead of print]

44. Adams RB Jr, Franklin RG Jr, Rule NO, Freeman JB, Kveraga K, Hadjikhani N, Yoshikawa S, Ambady N. Culture, Gaze and the neural processing of fear expressions. Soc Cogn Affect Neurosci 2009 Dec 17 [epub ahead of print]

45. Walters RG, Jacquemont S, Valsesia A, de Smith AJ, Martinet D, Andersson J, Falchi M, Chen F, Andrieux J, Lobbens S, Delobel B, Stutzmann F, El-Sayed Moustafa JS, Chèvre JC, Lecoeur C, Vatin V, Bouquillon S, Boute O, Cuisset JM, Ambresin AE, Brioshi A , Gaillard M, Giusti V, Fellmann F, Ferrarini A, Hadjikhani N, Campion D, Goldenberg A, Calmels N, Mandel JL, Le Caignec C, David A, Isidor B, Cordier MP, Dupuis-Girod S, Labalme A, Sanlaville D, Béri-Deixheimer M, Jonveaux P, Leheup B, Õunap K, Ellis R, MacDermot KD, Vincent-Delorme C, Plessis G, Touraine R, Philippe A, Malin V, Blaumeiser B, Frank Kooy RF, Caiazzo R, Pigeyre M, Balkau B, Sladek R, Bergmann S, Mooser V, Waterworth D, Reymond A, Vollenweider P, Waeber G, Kurg A, Palta P, Esko T, Metspalu A, Nelis M, Elliott P, Hartikainen AL, McCarthy MI, Peltonen L, Carlsson L, Jacobson P, Sjöström L, Männik K, Jarvelin MR, Pattou F, Meyre D, Walley AJ, Coin LJM, Blakemore AIF, Froguel P, Beckmann JS. A novel highly-penetrant form of obesity due to a 740kb deletion on chromosome 16p11.2. Nature, 2010:463;671-675

46. Jacquemont S, Curie A. Des Portes V, Torrioli MA, Berry-Kravis E, Hagerman R, Ramos FJ, Cornish K, He Y, Paulding C, Neri G, Chen F, Hadjikhani N, Martinet D, Meyer J, Beckmann JS, Delange K, Brun A, Bussy G, Gasparini F, Hilse T, Floesser A, Branson J, Bilbe G, Johns D, Gomez-Mancilla B. Epigenetic modification of the FMR1 gene in fragile X leads to a differential response to the mGluR5 antagonist AFQ056. Science Translational Medicine 2011 Vol. 3, Issue 64, p. 64ra1.

47. Granziera C, Hadjikhani N, Arzy S, Seeck M, Meuli R, Krueger G. In vivo imaging of the structural core of Papez circuit in humans. NeuroReport 2011;22(5)227-31.

Adams RB, Franklin RG, Kveraga K, Ambady N, Kleck RE, Whalen P, Hadjikhani N, Nelson AJ. Amygdala responses to averted vs irect gaze fear vary as a function of presentation speed. Soc Cogn Affect Neurosci Neuroscience 2012;7(5):568-77

49. Mainero C, Boshyan J, Hadjikhani N. Altered functional resting-state connectivity in the periacqueductal gray networks in migraine. Annals of Neurology 2011,70(2):838-845.

Donnelly N, Zurcher N, Cornes K, Snyder J, Naik P, Hadwin J, Hadjikhani N. Discriminating grotesque from typical faces: evidence from the Thatcher illusion. PLoS One. 2011;6(8):e23340

51. Van der Zwaag W, Da Costa S, Zurcher N.R, Adams R.B, Hadjikhani N. A 7 Tesla fMRI study of amygdala response to fearful faces. Brain Topography. 2012; Apr;25(2):125-8.

Van den Stock J, Vandenbulcke M, Zhu Q, Hadjikhani N, de Gelder B. Developmental prosopagnosia in a patient with hypoplasia of the vermis cerebelli. Neurology 2012, 78(21) :1700-1702.

53. Granziera C, Daducci A, Meskaldji D, Roche A, Maeder P, Michel P, Hadjikhani N, Sorensen G, Frackowiak R, Thiran J.P., Meuli R, Krueger G. A new early and automated MRI-based predictor of motor improvement after stroke Neurology 2012; Jul 3;79(1):39-46

54. Norris B, Nadel J, Barker M, Hadjikhani N, Billard A. Investigating gaze of children with ASD in naturalistic settings. PLoS One 2012;7(9)e44144.

55. Bakhtiari R, Zurcher N, Rogier O, Russo B, Hippolyte L, Granziera C, Araabi B, Ahmadabadi M, Hadjikhani N. Differences in white matter reflect atypical developmental trajectory in autism: a tract-based spatial statistics study. NeuroImage: Clinical, 2012;1:48-56.

56. Lemonnier E, Degrez C, Phelep M, Tyzio R, Josse F, Grandgeorges M, Hadjikhani N, Ben-Ari Y. A randomized controlled trial of bumetanide in the treatment of autism in children. Translational Psychiatry 2012;2:e202

57. Zurcher N, Donnelly N, Rogier O, Russo B, Hippolyte L, Hadwin J, Lemonnier E, Hadjikhani N. It’s all in the eyes: subcortical and cortical activation during grotesqueness perception in autism. PLoS One 2013;8(1):e54313

58. Granziera C, Daducci A, Romascano D, Roche A, Helms G, Krueger G, Hadjikhani N. Structural abnormalities in the thalamus of migraineurs with aura: a multiparametric study at 3T. Human Brain Mapping 2014 Apr;35(4):1461-8 Epub 2013 Mar 1

59. Jiang X, Bollich A, Cox P, Hyder E, James J, Gowani SA, Hadjikhani N, Blanz V, Manoach DS, Barton JS, Gaillard WD, Riesenhuber M. A quantitative link between face discrimination deficits and neuronal selectivity for faces in autism. NeuroImage Clinical 2013; 2:320-321

60. Hadjikhani N. Ward N, Boshyan J, Napadow V, Maeda Y, Truini A, Caramia F, Tinelli E, Mainero C. The missing link: Enhanced functional connectivity between amygdala and the visceroceptive cortex in migraine. Cephalagia 2013, 33(15):1264-1268

61. Granziera C, Romascano D, Daducci A, Roche A, Vincent M, Krueger G, Hadjikhani N. Migraineurs without aura show microstructural abnormalities in the cerebellum and the frontal lobe. The Cerebellum 2013, Dec;12(6):812-8.

62. Meeren HKM, de Gelder B, Ahlfors SP, Hamalainen M, Hadjikhani N. Different cortical dynamics in face and body perception: an MEG study. PLoS ONE 2013;8(9)e71408

63. Sabatier I, Chabrier S, Brun A, Hees L, Cheylus A, Gollub R, Hadjikhani N, Kong J, des Portes V, Floret D, Curie A. Stroke by Carotid Artery Complete Occlusion in Kawasaki Disease: Case Report and Review of Literature. Pediatric Neurology 2013; Dec;49(6):469-73.

64. Zurcher N, Rogier O, Boshyan J, Hippolyte L, Russo B, Gillberg N, Helles A, Ruest T, Lemonnier E, Gillberg Ch, Hadjikhani N. Perception of social cues of danger in autism spectrum disorders. PLoS ONE 2013, Dec 4;8(12):e81206.

65. Hadjikhani N, Zurcher N, Rogier O, Ruest T, Hippolyte L, Ben-Ari Y, Lemonnier E. Improving emotional face perception in autism with diuretic bumetanide: a proof-of-concept behavioral and functional brain imaging pilot study. Autism 2015,19(2)149-157 (epub 2013 Dec 16 2013).

66. Bader M, Hadjikhani N. The concept of instability: a French perspective on the concept of ADHD. ADHD Attention Deficit and Hyperactivity Disorders, 2014 Mar;6(1):11-7.

67. Hadjikhani N, Zurcher NR, Rogier O, Hippolyte L, Lemonnier E, Ruest T, Ward N, Lassalle A, Gillberg N, Billstedt E, Helles A, Gillberg C, Solomon P, Pkrachin K, Gillberg C. Emotional contagion for pain is intact in Autism Spectrum Disorders. Translational Psychiatry 2014,4,e343.

68. Kveraga K, Boshyan J, Adams R, Mote J, Betz N, Ward N, Hadjikhani N, Bar M, Barrett L. If it bleeds, it leads: Separating threat and negativity. Social Cognitive and Affective Neuroscience, 2014, April 4 [Epub ahead of print].

69. Fernell E, Wilson P, Hadjikhani N, Bourgeron T, Neville B, Taylor D, Gillberg C. Screening, intervention and outcome in autism and other developmental disorders – the role of randomized controlled trials. Journal of Autism and Developmental Disorders, 2014 Aug;44(8):2074-6.

70. Curie A, Nazir T, Brun A, Paulignan Y, Reboul A, Delange K, Cheylus A, Bertrand S, Rochefort F, Bussy G, Marignier S, Lacombe D, Chiron C, Cossee M, Leheup B, Philippe C, Laugel V, De Saint Martin A, Sacco S, Poirier K, Bienvenu T, Souville I, Gilbert-Dussardier B, Bieth E, Kauffmann D, Briot P, de Freminville B, Prieur F, Till M, Rooryck-Thambo C, Mortemousque I, Bobillier-Chaumont I, Toutain A, Touraine R, Sanlaville D, Chelly J, Freeman S, Kong J, Hadjikhani N, Gollub RL, Roy A, des Portes V. The c.429_452 duplication of the ARX gene: a unique developmental-model of limb kinetic apraxia. Orphanet J Rare Dis. 2014 Feb 14;9(1):25.

71. Guillon Q, Hadjikhani N, Baduel S, Roge B. Visual social attention in Autism Spectrum Disorder: insights from eye tracking studies. Neuroscience & Biobehavioral Reviews 2014 (42):279-297

72. Durrleman S, Hippolyte L, Zufferey S, Iglesias K, Hadjikhani N. Complex Syntax in Autism Spectrum Disorders: A study of Relative Clauses. International Journal of Language & Communication Disorders 2014 Sep 19. [Epub ahead of print]

73. Guillon Q, Hadjikhani N, Baduel S, Kruck J, Arnaud M, Roge B. Both dog and human faces are explored abnormally by young children with autism spectrum disorders. NeuroReport 2014 Oct 22;25(15):1237-41

74. Maillard A, Ruef A, Pizzagalli F, Migliavacca E, Hippolyte L, Adaszewski S, Dukart J, Ferrari F, Conus Ph, Männik K, Zazhytska M, Siffredi V, Maeder Ph, Kutalik Z, Kherif F, Hadjikhani N, Beckmann J, Reymond A, Draganski B, Jacquemont S. 2014 The 16p11.2 locus modulates brain structures common to autism, schizophrenia and obesity. Molecular Psychiatry,2014 Nov 25. doi: 10.1038/mp.2014.145. [Epub ahead of print]

75. Hadjikhani N. Deconstructing scientifically some of the myths regarding autism.Swiss Archives of Neurology and Psychiatry, 2014;165(8):272-6

76. Dahlem MA, Schmidt B, Bojak I, Boie S, Kneer F, Hadjikhani N, Kurths Hot spots and labyrinths: Why cortical neuromodulation for episodic migraine with aura should be personalized. Frontiers in Computational Neuroscience, 2015 [Epub Feb 18 2015]

77. Guillon Q, Hadjikhani N, Roge B. L’utilisation de la technique de suivi du regard dans l’etude des trouble du spectre de l’autisme. L’Information Psychiatrique, 2014 90(10) 827-34.

78. Østergaard L, Dreier JP, Hadjikhani N, Jespersen SN, Dirnagl U, Dalkara T. Neurovascular coupling during cortical spreading depolarization and depression. Stroke 2015 in press.

79. Guillon Q, Afzali MH, Roge B, Baduel S, Kruck J, Hadjikhani N. The importance of networking in autism gaze analysis. PLoS One 2015;10(10)e:0141191.

80. Hippolyte L, Maillard AM, Rodriguez-Herreros B, Pain A, Martin-Brevet S, Ferrari C, Conus P, Macé A, Hadjikhani N, Metspalu A, Reigo A, Kolk A, Männik K, Barker M, Isidor B, Le Caignec C, Mignot C, Schneider L, Mottron L, Keren B, Albert D, Doco-Fenzy M, Gérard M. Bernier R, Goin-Kochel RP, Hanson E, Green Snyder L, 16p11.2 European Consortium, The Simons VIP Consortium, Ramus F, Beckmann JS, Draganski B, Reymond A, Jacquemont S. The number of genomic copies at the 16p11.2 locus modulates language, verbal memory and inhibition. Biological Psychiatry 2015, in press

81. Kveraga K, Boshyan J, Ward N, Hadjikhani N, Adams R Jr. Vision for action : saccadic and manual responses to clear threat and ambiguous negative scenes. J Vis 2015 Sep1 ;15(12)

Publications - Books, book chapters and others

DaSilva A, Hadjikhani N. Human Thalamic Response to Experimental Pain (Neuroimaging). In: Encyclopedic Reference of Pain. Springer-Verlag 2006.

Hadjikhani N. Mirror Neuron System in Autism. In: Progress In Autism Research. Nova Science Publishers New York, NY 2007. p. 151-166.

Granziera, C Hadjikhani, N. Surface-Based Structural Changes in Migraine. In: The Migraine Brain, Imaging Structure and Function. Oxford University Press 2012.

Hadjikhani, N Vincent, M. Visual Aura. In: The Migraine Brain, Imaging Structure and Function. Oxford University Press 2012.

Hadjikhani, N. Frontal Lobes Findings in Autism. In: Encyclopedia of Autism Spectrum Disorders. Springer 2012.

DaSilva A, Hadjikhani N. Human Thalamic Response to Experimental Pain (Neuroimaging). In: Encyclopedic Reference of Pain. Springer-Verlag 2013.

Hadjikhani N, Guillon Q. Zeroing in on illusions in eye-gaze research. Guest Blog, Simons Foundation for Autism Research Initiative (SFARI) 2014

Y Ben-Ari, E Lemonnier, N. Hadjikhani. Traiter l’autisme? Au-dela des genes et de la psychanalyse. De Boeck Solal, 2015

Allely C.S., Hadjikhani N., Toro R. and Gillberg C. (2015) Neuropsychiatry. In: Arthur W. Toga, editor. Brain Mapping: An Encyclopedic Reference, vol3, pp. 1049-1060. Academic Press: Elsevier

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